Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
Drug resistance invariably limits the response of oncogene-addicted cancer cells to targeted therapy. The upregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a mechanism of drug resistance in a range of oncogene-addicted cancers. However, the development...
Main Authors: | Matilda Lee, Jayshree L. Hirpara, Jie-Qing Eu, Gautam Sethi, Lingzhi Wang, Boon-Cher Goh, Andrea L. Wong |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-07-01
|
Series: | Redox Biology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221323171830908X |
Similar Items
-
Glutamine addiction in tumor cell: oncogene regulation and clinical treatment
by: Xian Li, et al.
Published: (2024-01-01) -
Multistep Phosphorylation by Oncogenic Kinases Enhances the Degradation of the NF2 Tumor Suppressor Merlin
by: Minja Laulajainen, et al.
Published: (2011-07-01) -
Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers
by: Marie Brachet-Botineau, et al.
Published: (2020-01-01) -
Targeting Non-Oncogene Addiction for Cancer Therapy
by: Hae Ryung Chang, et al.
Published: (2021-01-01) -
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
by: Jiaqi Li, et al.
Published: (2020-10-01)