Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice
Black phosphorus quantum dots (BPQDs) are considered to have wide application prospects due to their excellent properties. However, there is no study on the effect of BPQDs on glucose metabolism. In this study, blood glucose was significantly increased when mice were continuously intragastrically ad...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322010089 |
| _version_ | 1811325316931518464 |
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| author | Jie Zeng Fengkai Ruan Mingtao Wu Jiaying Xu Zhenghong Zuo Yi Yu Chengyong He |
| author_facet | Jie Zeng Fengkai Ruan Mingtao Wu Jiaying Xu Zhenghong Zuo Yi Yu Chengyong He |
| author_sort | Jie Zeng |
| collection | DOAJ |
| description | Black phosphorus quantum dots (BPQDs) are considered to have wide application prospects due to their excellent properties. However, there is no study on the effect of BPQDs on glucose metabolism. In this study, blood glucose was significantly increased when mice were continuously intragastrically administered 0.1 and 1 mg/kg bw BPQDs. The blood glucose level of the mice was elevated from Day 7 to Day 28. BPQD exposure also decreased the area under the curve (AUC) of the oral glucose tolerance test (OGTT). After exposure, the pancreas somatic index was increased. Moreover, the serum insulin and glucagon levels were elevated and the relative area of islet β cells was increased in BPQD-exposed mice, while insulin signaling cascades were reduced in muscle tissues. In summary, our study demonstrated for the first time that BPQD exposure induces glucose disorder and insulin resistance in muscle, which is helpful to understand the biosafety of black phosphorus nanomaterials and promote the sustainable development of nanotechnology. |
| first_indexed | 2024-04-13T14:30:55Z |
| format | Article |
| id | doaj.art-b33071427c2746c89ca8806fd3028d72 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-13T14:30:55Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-b33071427c2746c89ca8806fd3028d722022-12-22T02:43:11ZengElsevierEcotoxicology and Environmental Safety0147-65132022-11-01246114168Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in miceJie Zeng0Fengkai Ruan1Mingtao Wu2Jiaying Xu3Zhenghong Zuo4Yi Yu5Chengyong He6State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaCorresponding authors.; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaCorresponding authors.; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Shenzhen Research Institute of Xiamen University, Fujian Clinical Research Center for Chronic Glomerular Disease, Department of Nephrology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, ChinaBlack phosphorus quantum dots (BPQDs) are considered to have wide application prospects due to their excellent properties. However, there is no study on the effect of BPQDs on glucose metabolism. In this study, blood glucose was significantly increased when mice were continuously intragastrically administered 0.1 and 1 mg/kg bw BPQDs. The blood glucose level of the mice was elevated from Day 7 to Day 28. BPQD exposure also decreased the area under the curve (AUC) of the oral glucose tolerance test (OGTT). After exposure, the pancreas somatic index was increased. Moreover, the serum insulin and glucagon levels were elevated and the relative area of islet β cells was increased in BPQD-exposed mice, while insulin signaling cascades were reduced in muscle tissues. In summary, our study demonstrated for the first time that BPQD exposure induces glucose disorder and insulin resistance in muscle, which is helpful to understand the biosafety of black phosphorus nanomaterials and promote the sustainable development of nanotechnology.http://www.sciencedirect.com/science/article/pii/S0147651322010089Black phosphorus quantum dotsInsulin resistanceNano safetyMetabolic disorders |
| spellingShingle | Jie Zeng Fengkai Ruan Mingtao Wu Jiaying Xu Zhenghong Zuo Yi Yu Chengyong He Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice Ecotoxicology and Environmental Safety Black phosphorus quantum dots Insulin resistance Nano safety Metabolic disorders |
| title | Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| title_full | Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| title_fullStr | Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| title_full_unstemmed | Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| title_short | Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| title_sort | black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice |
| topic | Black phosphorus quantum dots Insulin resistance Nano safety Metabolic disorders |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322010089 |
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