Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports
Abstract Background To report three cases of congenital corneal opacity where intraocular pressure (IOP) readings were high despite the use of multiple anti-glaucoma eye drops and normalized after corneal transplantation. Case presentation Three Korean infants presented with bilateral dense stromal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-019-1287-7 |
| _version_ | 1818662286910291968 |
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| author | Byeong Soo Kang Jin Wook Jeoung Joo Youn Oh |
| author_facet | Byeong Soo Kang Jin Wook Jeoung Joo Youn Oh |
| author_sort | Byeong Soo Kang |
| collection | DOAJ |
| description | Abstract Background To report three cases of congenital corneal opacity where intraocular pressure (IOP) readings were high despite the use of multiple anti-glaucoma eye drops and normalized after corneal transplantation. Case presentation Three Korean infants presented with bilateral dense stromal opacification which had been present since birth. IOPs measured by rebound tonometer were high despite administration of multiple anti-glaucoma medications. One eye of each patient underwent penetrating keratoplasty (PK) because corneal opacity impaired visual development. Immediately after PK, IOPs were normalized and maintained normal without medication, whereas they remained high in the contralateral unoperated eye. On histology, stromal fibrosis was observed in the removed corneal button, and molecular assays revealed increased levels of type 1 and 5 collagens. Conclusion The IOP measurement using the conventional applanation-based tonometry can be inaccurate in congenital corneal opacity which is marked by corneal fibrosis. Therefore, IOP values should be interpreted with caution in these patients, and the possibility of false-positive diagnosis of glaucoma considered. |
| first_indexed | 2024-12-17T04:58:33Z |
| format | Article |
| id | doaj.art-b332ddd3997e4f09bcf3acebd3a91396 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-17T04:58:33Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-b332ddd3997e4f09bcf3acebd3a913962022-12-21T22:02:38ZengBMCBMC Ophthalmology1471-24152020-01-012011510.1186/s12886-019-1287-7Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reportsByeong Soo Kang0Jin Wook Jeoung1Joo Youn Oh2Department of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineDepartment of Ophthalmology, Seoul National University College of MedicineAbstract Background To report three cases of congenital corneal opacity where intraocular pressure (IOP) readings were high despite the use of multiple anti-glaucoma eye drops and normalized after corneal transplantation. Case presentation Three Korean infants presented with bilateral dense stromal opacification which had been present since birth. IOPs measured by rebound tonometer were high despite administration of multiple anti-glaucoma medications. One eye of each patient underwent penetrating keratoplasty (PK) because corneal opacity impaired visual development. Immediately after PK, IOPs were normalized and maintained normal without medication, whereas they remained high in the contralateral unoperated eye. On histology, stromal fibrosis was observed in the removed corneal button, and molecular assays revealed increased levels of type 1 and 5 collagens. Conclusion The IOP measurement using the conventional applanation-based tonometry can be inaccurate in congenital corneal opacity which is marked by corneal fibrosis. Therefore, IOP values should be interpreted with caution in these patients, and the possibility of false-positive diagnosis of glaucoma considered.https://doi.org/10.1186/s12886-019-1287-7Applanation-based tonometryCase reportCongenital corneal opacityCongenital glaucomaIntraocular pressure |
| spellingShingle | Byeong Soo Kang Jin Wook Jeoung Joo Youn Oh Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports BMC Ophthalmology Applanation-based tonometry Case report Congenital corneal opacity Congenital glaucoma Intraocular pressure |
| title | Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports |
| title_full | Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports |
| title_fullStr | Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports |
| title_full_unstemmed | Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports |
| title_short | Inaccuracy of intraocular pressure measurement in congenital corneal opacity: three case reports |
| title_sort | inaccuracy of intraocular pressure measurement in congenital corneal opacity three case reports |
| topic | Applanation-based tonometry Case report Congenital corneal opacity Congenital glaucoma Intraocular pressure |
| url | https://doi.org/10.1186/s12886-019-1287-7 |
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