Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China
Objectives: Four seasonal coronaviruses, including human coronavirus (HCoV)-229E and HCoV-OC43, HCoV-NL63, and HCoV-HKU1 cause approximately 15-30% of common colds in adults. However, the full landscape of the immune trajectory to these viruses that covers the whole childhood period is still not wel...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222006361 |
| _version_ | 1797943112090255360 |
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| author | Yasha Luo Huibin Lv Shilin Zhao Yuanxin Sun Chengyi Liu Chunke Chen Weiwen Liang Kin-on Kwok Qi Wen Teo Ray TY So Yihan Lin Yuhong Deng Biyun Li Zixi Dai Jie Zhu Dengwei Zhang Julia Fernando Nicholas C Wu Hein M. Tun Roberto Bruzzone Chris KP Mok Xiaoping Mu |
| author_facet | Yasha Luo Huibin Lv Shilin Zhao Yuanxin Sun Chengyi Liu Chunke Chen Weiwen Liang Kin-on Kwok Qi Wen Teo Ray TY So Yihan Lin Yuhong Deng Biyun Li Zixi Dai Jie Zhu Dengwei Zhang Julia Fernando Nicholas C Wu Hein M. Tun Roberto Bruzzone Chris KP Mok Xiaoping Mu |
| author_sort | Yasha Luo |
| collection | DOAJ |
| description | Objectives: Four seasonal coronaviruses, including human coronavirus (HCoV)-229E and HCoV-OC43, HCoV-NL63, and HCoV-HKU1 cause approximately 15-30% of common colds in adults. However, the full landscape of the immune trajectory to these viruses that covers the whole childhood period is still not well understood. Methods: We evaluated the serological responses against the four seasonal coronaviruses in 1886 children aged under 18 years by using enzyme-linked immunosorbent assay. The optical density values against each HCoV were determined from each sample. Generalized additive models were constructed to determine the relationship between age and seroprevalence throughout the whole childhood period. The specific antibody levels against the four seasonal coronaviruses were also tested from the plasma samples of 485 pairs of postpartum women and their newborn babies. Results: The immunoglobulin (Ig) G levels of the four seasonal coronaviruses in the mother and the newborn babies were highly correlated (229E: r = 0.63; OC43: r = 0.65; NL63: r = 0.69; HKU1: r = 0.63). The seroprevalences in children showed a similar trajectory in that the levels of IgG in the neonates dropped significantly and reached the lowest level after the age of around 1 year (229E: 1.18 years; OC43: 0.97 years; NL63: 1.01 years; HKU1: 1.02 years) and then resurgence in the children who aged older than 1 year. Using the lowest level from the generalized additive models as our cutoff, the seroprevalences for HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 were 98.11%, 96.23%, 96.23% and 94.34% at the age of 16-18 years. Conclusion: Mothers share HCoV-specific IgGs with their newborn babies and the level of maternal IgGs waned at around 1 year after birth. The resurgence of the HCoV-specific IgGs was found thereafter with the increase in age suggesting repeated infection occurred in children. |
| first_indexed | 2024-04-10T20:18:06Z |
| format | Article |
| id | doaj.art-b33320e3882b4422a04173ec280b588b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-10T20:18:06Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-b33320e3882b4422a04173ec280b588b2023-01-26T04:44:35ZengElsevierInternational Journal of Infectious Diseases1201-97122023-02-011272632Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, ChinaYasha Luo0Huibin Lv1Shilin Zhao2Yuanxin Sun3Chengyi Liu4Chunke Chen5Weiwen Liang6Kin-on Kwok7Qi Wen Teo8Ray TY So9Yihan Lin10Yuhong Deng11Biyun Li12Zixi Dai13Jie Zhu14Dengwei Zhang15Julia Fernando16Nicholas C Wu17Hein M. Tun18Roberto Bruzzone19Chris KP Mok20Xiaoping Mu21Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR ChinaLi Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, ChinaDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USAHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, ChinaDepartment of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Chemistry and The Swire Institute of Marine Science, The University of Hong Kong, Pokfulam Road, Hong Kong, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, USA; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, USA; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, USAHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, ChinaHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaLi Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China; Corresponding authors:Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China; Corresponding authors:Objectives: Four seasonal coronaviruses, including human coronavirus (HCoV)-229E and HCoV-OC43, HCoV-NL63, and HCoV-HKU1 cause approximately 15-30% of common colds in adults. However, the full landscape of the immune trajectory to these viruses that covers the whole childhood period is still not well understood. Methods: We evaluated the serological responses against the four seasonal coronaviruses in 1886 children aged under 18 years by using enzyme-linked immunosorbent assay. The optical density values against each HCoV were determined from each sample. Generalized additive models were constructed to determine the relationship between age and seroprevalence throughout the whole childhood period. The specific antibody levels against the four seasonal coronaviruses were also tested from the plasma samples of 485 pairs of postpartum women and their newborn babies. Results: The immunoglobulin (Ig) G levels of the four seasonal coronaviruses in the mother and the newborn babies were highly correlated (229E: r = 0.63; OC43: r = 0.65; NL63: r = 0.69; HKU1: r = 0.63). The seroprevalences in children showed a similar trajectory in that the levels of IgG in the neonates dropped significantly and reached the lowest level after the age of around 1 year (229E: 1.18 years; OC43: 0.97 years; NL63: 1.01 years; HKU1: 1.02 years) and then resurgence in the children who aged older than 1 year. Using the lowest level from the generalized additive models as our cutoff, the seroprevalences for HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 were 98.11%, 96.23%, 96.23% and 94.34% at the age of 16-18 years. Conclusion: Mothers share HCoV-specific IgGs with their newborn babies and the level of maternal IgGs waned at around 1 year after birth. The resurgence of the HCoV-specific IgGs was found thereafter with the increase in age suggesting repeated infection occurred in children.http://www.sciencedirect.com/science/article/pii/S1201971222006361Coronaviruses: ChildrenSerologyIgG |
| spellingShingle | Yasha Luo Huibin Lv Shilin Zhao Yuanxin Sun Chengyi Liu Chunke Chen Weiwen Liang Kin-on Kwok Qi Wen Teo Ray TY So Yihan Lin Yuhong Deng Biyun Li Zixi Dai Jie Zhu Dengwei Zhang Julia Fernando Nicholas C Wu Hein M. Tun Roberto Bruzzone Chris KP Mok Xiaoping Mu Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China International Journal of Infectious Diseases Coronaviruses: Children Serology IgG |
| title | Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China |
| title_full | Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China |
| title_fullStr | Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China |
| title_full_unstemmed | Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China |
| title_short | Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China |
| title_sort | age related seroprevalence trajectories of seasonal coronaviruses in children including neonates in guangzhou china |
| topic | Coronaviruses: Children Serology IgG |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222006361 |
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