Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Epstein-Barr virus (EBV) nuclear oncoprotein EBNA3C is essential for B-cell transformation and development of several B-cell lymphomas particularly those are generated in an immuno-compromised background. EBNA3C recruits ubiquitin-proteasome machinery for deregulating multiple cellular oncoproteins...

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Bibliographic Details
Main Authors: Chandrima Gain, Samaresh Malik, Shaoni Bhattacharjee, Arijit Ghosh, Erle S Robertson, Benu Brata Das, Abhik Saha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008105

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https://doi.org/10.1371/journal.ppat.1008105

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