Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer
Background and objective Precious studies proven that the overexpression of eukaryotic translation initiation factor 4E (eIF4E) in a variety of solid tumors has linked with malignant tumorigenesis, invasion and metastasis. The aim of this work is to explore the expression of eIF4E and its clinical s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-12-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.12.10&path[]=2727 |
| _version_ | 1819071085336854528 |
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| author | Bo ZHANG Chengchu ZHU Baofu CHEN Xia ZHANG Minhua YE Aifen LIN |
| author_facet | Bo ZHANG Chengchu ZHU Baofu CHEN Xia ZHANG Minhua YE Aifen LIN |
| author_sort | Bo ZHANG |
| collection | DOAJ |
| description | Background and objective Precious studies proven that the overexpression of eukaryotic translation initiation factor 4E (eIF4E) in a variety of solid tumors has linked with malignant tumorigenesis, invasion and metastasis. The aim of this work is to explore the expression of eIF4E and its clinical significance in non-small cell lung cancer (NSCLC) through immunohistochemical method. Methods Seventy NSCLC specimens were constructed into tissue microarray, simultaneously took 19 cases adjacent tissues and 20 cases normal lung tissue as control, all performed using immunohistochemistry (Envision). Results eIF4E expression in NSCLC was significantly higher than that in adjacent tissues and normal lung tissues, statistically significant difference between the groups. The eIF4E positive expression in lymph node metastasis group was significantly higher than that in no-lymph node metastasis. eIF4E protein positive expression of WD/MD cancer tissue was significantly lower than those in PD/ND cancer tissue. There were no significant differences of positive expression of eIF4E with the tumor diameter, age, smoking status, gender of NSCLC patients (P>0.05). Conclusion There were highly over expression rate of eIF4E, and closely correlated with lymphnode metastasis in NSCLC, which implies that the eIF4E expression may be related to tumorgenesis, invasion and metastasis of lung cancer. eIF4E may be a new marker for lung cancer and objective indicators assessing the development of lung cancer. |
| first_indexed | 2024-12-21T17:16:13Z |
| format | Article |
| id | doaj.art-b338de5b4b254169ae15f4651f0a1063 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-21T17:16:13Z |
| publishDate | 2010-12-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-b338de5b4b254169ae15f4651f0a10632022-12-21T18:56:18ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872010-12-01131211321135Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung CancerBo ZHANGChengchu ZHUBaofu CHENXia ZHANGMinhua YEAifen LINBackground and objective Precious studies proven that the overexpression of eukaryotic translation initiation factor 4E (eIF4E) in a variety of solid tumors has linked with malignant tumorigenesis, invasion and metastasis. The aim of this work is to explore the expression of eIF4E and its clinical significance in non-small cell lung cancer (NSCLC) through immunohistochemical method. Methods Seventy NSCLC specimens were constructed into tissue microarray, simultaneously took 19 cases adjacent tissues and 20 cases normal lung tissue as control, all performed using immunohistochemistry (Envision). Results eIF4E expression in NSCLC was significantly higher than that in adjacent tissues and normal lung tissues, statistically significant difference between the groups. The eIF4E positive expression in lymph node metastasis group was significantly higher than that in no-lymph node metastasis. eIF4E protein positive expression of WD/MD cancer tissue was significantly lower than those in PD/ND cancer tissue. There were no significant differences of positive expression of eIF4E with the tumor diameter, age, smoking status, gender of NSCLC patients (P>0.05). Conclusion There were highly over expression rate of eIF4E, and closely correlated with lymphnode metastasis in NSCLC, which implies that the eIF4E expression may be related to tumorgenesis, invasion and metastasis of lung cancer. eIF4E may be a new marker for lung cancer and objective indicators assessing the development of lung cancer.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.12.10&path[]=2727Lung neoplasmsImmunohistochemistryEukaryotic initiation factor-4E |
| spellingShingle | Bo ZHANG Chengchu ZHU Baofu CHEN Xia ZHANG Minhua YE Aifen LIN Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Immunohistochemistry Eukaryotic initiation factor-4E |
| title | Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer |
| title_full | Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer |
| title_fullStr | Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer |
| title_full_unstemmed | Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer |
| title_short | Expression and Its Clinical Significance of eIF4E in Non-small Cell Lung Cancer |
| title_sort | expression and its clinical significance of eif4e in non small cell lung cancer |
| topic | Lung neoplasms Immunohistochemistry Eukaryotic initiation factor-4E |
| url | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.12.10&path[]=2727 |
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