Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study
Introduction: Feeding intolerance is common among the preterm neonates and is associated with different comorbidities like respiratory depression, respiratory distress syndrome, apnea, hyperbilirubinaemia, and hypoxic ischaemic encephalopathy. Aim: To find the incidence of feeding intolerance in...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15228/49172_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
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| author | Binod Kumar Gupta Ranjana Bista Sandeep Shrestha Deepak Raj BhandarI Raju Kaphle Dinesh Chaudhary Nagendra Chaudhary |
| author_facet | Binod Kumar Gupta Ranjana Bista Sandeep Shrestha Deepak Raj BhandarI Raju Kaphle Dinesh Chaudhary Nagendra Chaudhary |
| author_sort | Binod Kumar Gupta |
| collection | DOAJ |
| description | Introduction: Feeding intolerance is common among the
preterm neonates and is associated with different comorbidities like respiratory depression, respiratory distress
syndrome, apnea, hyperbilirubinaemia, and hypoxic ischaemic
encephalopathy.
Aim: To find the incidence of feeding intolerance in preterm
neonates from 28-34 weeks of gestation along with the clinical
signs and co-morbidities associated with feeding intolerance.
Materials and Methods: A prospective observational hospital
based study was conducted in Neonatal Intensive Care Unit
(NICU) and postnatal ward of Universal College of Medical
Sciences, a tertiary care hospital situated in western Nepal
for 12 months (June 2018 to May 2019). All admitted preterm
neonates between 28-34 weeks of gestation were included in
the study and were followed-up for any neonatal morbidities
along with feeding intolerance. Feeding intolerance was defined
when the newborn had vomiting and/or abdominal distension
and/or increased gastric residual volume with normal disruption
of feeding process. Babies with feeding intolerance were
subjected to final analysis for clinical signs and co-morbidities.
Results: Out of 490 admitted preterm babies (28-34 weeks),
54 (11.02%) had feeding intolerance with 33 (61.1%) babies
in the very low birth weight group. The mean birth weights of
the total enrolled babies (n=490) and feed intolerant (n=54)
babies were 1550 gm and 1418 gm, respectively. Different comorbidities associated with feeding intolerance were respiratory
distress (25.9%), respiratory distress syndrome (22.2%),
jaundice (16.7%), apnea (5.6%) and necrotising enterocolitis
(3.7%). Among the total 37 preterm deaths, four babies were
in the feeding intolerance group. Majority of all feed intolerant
babies had vomiting 49 (90.7%) followed by gastric residue
(57.4%), abdominal distension (55.6%), and reduced or absent
bowel sounds (7.4%), respectively. The incidence of feeding
intolerance was increased in babies fed with formula feed
(p=0.46) and when feeding was started <24 hours (p=0.22) but
the results were statistically insignificant.
Conclusion: The incidence of feeding intolerance was 11.02%
in the preterm neonates (28-34 weeks) with high proportion
in very low birth weight babies. Vomiting, gastric residue and
abdominal distension were three important signs of feeding
intolerance in newborns. |
| first_indexed | 2024-12-17T20:03:26Z |
| format | Article |
| id | doaj.art-b33c8ebf8915406e938c5604c955b78a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-17T20:03:26Z |
| publishDate | 2021-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b33c8ebf8915406e938c5604c955b78a2022-12-21T21:34:23ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158SC01SC0510.7860/JCDR/2021/49172.15228Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational StudyBinod Kumar Gupta0 Ranjana Bista1Sandeep Shrestha2Deepak Raj BhandarI3Raju Kaphle4Dinesh Chaudhary5Nagendra Chaudhary6Associate Professor, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Junior Resident, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Assistant Professor, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Consultant Pediatrician, Department of Paediatrics, Kirtipur Hospital Kathmandu, Bagmati, Nepal.Associate Professor, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Assistant Professor, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Associate Professor, Department of Paediatrics, Universal College of Medical Sciences, Bhairahawa, Nepal.Introduction: Feeding intolerance is common among the preterm neonates and is associated with different comorbidities like respiratory depression, respiratory distress syndrome, apnea, hyperbilirubinaemia, and hypoxic ischaemic encephalopathy. Aim: To find the incidence of feeding intolerance in preterm neonates from 28-34 weeks of gestation along with the clinical signs and co-morbidities associated with feeding intolerance. Materials and Methods: A prospective observational hospital based study was conducted in Neonatal Intensive Care Unit (NICU) and postnatal ward of Universal College of Medical Sciences, a tertiary care hospital situated in western Nepal for 12 months (June 2018 to May 2019). All admitted preterm neonates between 28-34 weeks of gestation were included in the study and were followed-up for any neonatal morbidities along with feeding intolerance. Feeding intolerance was defined when the newborn had vomiting and/or abdominal distension and/or increased gastric residual volume with normal disruption of feeding process. Babies with feeding intolerance were subjected to final analysis for clinical signs and co-morbidities. Results: Out of 490 admitted preterm babies (28-34 weeks), 54 (11.02%) had feeding intolerance with 33 (61.1%) babies in the very low birth weight group. The mean birth weights of the total enrolled babies (n=490) and feed intolerant (n=54) babies were 1550 gm and 1418 gm, respectively. Different comorbidities associated with feeding intolerance were respiratory distress (25.9%), respiratory distress syndrome (22.2%), jaundice (16.7%), apnea (5.6%) and necrotising enterocolitis (3.7%). Among the total 37 preterm deaths, four babies were in the feeding intolerance group. Majority of all feed intolerant babies had vomiting 49 (90.7%) followed by gastric residue (57.4%), abdominal distension (55.6%), and reduced or absent bowel sounds (7.4%), respectively. The incidence of feeding intolerance was increased in babies fed with formula feed (p=0.46) and when feeding was started <24 hours (p=0.22) but the results were statistically insignificant. Conclusion: The incidence of feeding intolerance was 11.02% in the preterm neonates (28-34 weeks) with high proportion in very low birth weight babies. Vomiting, gastric residue and abdominal distension were three important signs of feeding intolerance in newborns.https://jcdr.net/articles/PDF/15228/49172_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdfabdominal distensionnecrotising enterocolitisvomiting |
| spellingShingle | Binod Kumar Gupta Ranjana Bista Sandeep Shrestha Deepak Raj BhandarI Raju Kaphle Dinesh Chaudhary Nagendra Chaudhary Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study Journal of Clinical and Diagnostic Research abdominal distension necrotising enterocolitis vomiting |
| title | Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study |
| title_full | Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study |
| title_fullStr | Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study |
| title_full_unstemmed | Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study |
| title_short | Incidence, Clinical Signs and Co-morbidities of Feeding Intolerance among Preterm Infants Aged 28-34 Weeks of Gestation in a Tertiary Care Hospital of Western NepalA Prospective Observational Study |
| title_sort | incidence clinical signs and co morbidities of feeding intolerance among preterm infants aged 28 34 weeks of gestation in a tertiary care hospital of western nepala prospective observational study |
| topic | abdominal distension necrotising enterocolitis vomiting |
| url | https://jcdr.net/articles/PDF/15228/49172_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
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