Effects of a multi-herbal extract on type 2 diabetes

<p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <i...

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Main Authors: Cho Su-In, Kang Young-Mi, Yeo Jiyoung, Jung Myeong-Ho
Format: Article
Language:English
Published: BMC 2011-03-01
Series:Chinese Medicine
Online Access:http://www.cmjournal.org/content/6/1/10
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author Cho Su-In
Kang Young-Mi
Yeo Jiyoung
Jung Myeong-Ho
author_facet Cho Su-In
Kang Young-Mi
Yeo Jiyoung
Jung Myeong-Ho
author_sort Cho Su-In
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <it>Evodia officinalis </it>was investigated for its anti-diabetic effects in cell and animal models.</p> <p>Methods</p> <p>Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in <it>db/db </it>mice (a genetic animal model for type 2 diabetes).</p> <p>Results</p> <p>While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The <it>db/db </it>mice treated with the extract showed reduced fasting blood glucose and HbA<sub>1c </sub>levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.</p> <p>Conclusion</p> <p>The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.</p>
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spelling doaj.art-b33e1f3111ba4c05aa82e0705f441b4c2022-12-22T00:57:19ZengBMCChinese Medicine1749-85462011-03-01611010.1186/1749-8546-6-10Effects of a multi-herbal extract on type 2 diabetesCho Su-InKang Young-MiYeo JiyoungJung Myeong-Ho<p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <it>Evodia officinalis </it>was investigated for its anti-diabetic effects in cell and animal models.</p> <p>Methods</p> <p>Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in <it>db/db </it>mice (a genetic animal model for type 2 diabetes).</p> <p>Results</p> <p>While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The <it>db/db </it>mice treated with the extract showed reduced fasting blood glucose and HbA<sub>1c </sub>levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.</p> <p>Conclusion</p> <p>The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.</p>http://www.cmjournal.org/content/6/1/10
spellingShingle Cho Su-In
Kang Young-Mi
Yeo Jiyoung
Jung Myeong-Ho
Effects of a multi-herbal extract on type 2 diabetes
Chinese Medicine
title Effects of a multi-herbal extract on type 2 diabetes
title_full Effects of a multi-herbal extract on type 2 diabetes
title_fullStr Effects of a multi-herbal extract on type 2 diabetes
title_full_unstemmed Effects of a multi-herbal extract on type 2 diabetes
title_short Effects of a multi-herbal extract on type 2 diabetes
title_sort effects of a multi herbal extract on type 2 diabetes
url http://www.cmjournal.org/content/6/1/10
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