Effects of a multi-herbal extract on type 2 diabetes
<p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <i...
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Format: | Article |
Language: | English |
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BMC
2011-03-01
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Series: | Chinese Medicine |
Online Access: | http://www.cmjournal.org/content/6/1/10 |
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author | Cho Su-In Kang Young-Mi Yeo Jiyoung Jung Myeong-Ho |
author_facet | Cho Su-In Kang Young-Mi Yeo Jiyoung Jung Myeong-Ho |
author_sort | Cho Su-In |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <it>Evodia officinalis </it>was investigated for its anti-diabetic effects in cell and animal models.</p> <p>Methods</p> <p>Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in <it>db/db </it>mice (a genetic animal model for type 2 diabetes).</p> <p>Results</p> <p>While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The <it>db/db </it>mice treated with the extract showed reduced fasting blood glucose and HbA<sub>1c </sub>levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.</p> <p>Conclusion</p> <p>The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.</p> |
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format | Article |
id | doaj.art-b33e1f3111ba4c05aa82e0705f441b4c |
institution | Directory Open Access Journal |
issn | 1749-8546 |
language | English |
last_indexed | 2024-12-11T17:16:39Z |
publishDate | 2011-03-01 |
publisher | BMC |
record_format | Article |
series | Chinese Medicine |
spelling | doaj.art-b33e1f3111ba4c05aa82e0705f441b4c2022-12-22T00:57:19ZengBMCChinese Medicine1749-85462011-03-01611010.1186/1749-8546-6-10Effects of a multi-herbal extract on type 2 diabetesCho Su-InKang Young-MiYeo JiyoungJung Myeong-Ho<p>Abstract</p> <p>Background</p> <p>An aqueous extract of multi-hypoglycemic herbs of <it>Panax ginseng </it>C.A.Meyer, <it>Pueraria lobata, Dioscorea batatas Decaisne, Rehmannia glutinosa, Amomum cadamomum Linné, Poncirus fructus </it>and <it>Evodia officinalis </it>was investigated for its anti-diabetic effects in cell and animal models.</p> <p>Methods</p> <p>Activities of PPARγ agonist, anti-inflammation, AMPK activator and anti-ER stress were measured in cell models and in <it>db/db </it>mice (a genetic animal model for type 2 diabetes).</p> <p>Results</p> <p>While the extract stimulated PPARγ-dependent luciferase activity and activated AMPK in C2C12 cells, it inhibited TNF-α-stimulated IKKβ/NFkB signaling and attenuated ER stress in HepG2 cells. The <it>db/db </it>mice treated with the extract showed reduced fasting blood glucose and HbA<sub>1c </sub>levels, improved postprandial glucose levels, enhanced insulin sensitivity and significantly decreased plasma free fatty acid, triglyceride and total cholesterol.</p> <p>Conclusion</p> <p>The aqueous extract of these seven hypoglycemic herbs demonstrated many therapeutic effects for the treatment of type 2 diabetes in cell and animal models.</p>http://www.cmjournal.org/content/6/1/10 |
spellingShingle | Cho Su-In Kang Young-Mi Yeo Jiyoung Jung Myeong-Ho Effects of a multi-herbal extract on type 2 diabetes Chinese Medicine |
title | Effects of a multi-herbal extract on type 2 diabetes |
title_full | Effects of a multi-herbal extract on type 2 diabetes |
title_fullStr | Effects of a multi-herbal extract on type 2 diabetes |
title_full_unstemmed | Effects of a multi-herbal extract on type 2 diabetes |
title_short | Effects of a multi-herbal extract on type 2 diabetes |
title_sort | effects of a multi herbal extract on type 2 diabetes |
url | http://www.cmjournal.org/content/6/1/10 |
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