The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans

Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load. This mutation load has the potential to shape patterns of adaptive evolution via genetic linkage to beneficial mutations. Here, we examine the effect of deleterious mutations on patterns o...

Полное описание

Библиографические подробности
Главные авторы: Katia Koelle, David A Rasmussen
Формат: Статья
Язык:English
Опубликовано: eLife Sciences Publications Ltd 2015-09-01
Серии:eLife
Предметы:
Online-ссылка:https://elifesciences.org/articles/07361