Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms
Cancer drug resistance stands as a formidable obstacle in the relentless fight against the top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for a significant portion of cancer-related deaths worldwide. In recent years, long...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024032389 |
| _version_ | 1797259733779873792 |
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| author | Yue Shi Joseph Adu-Amankwaah Qizhong Zhao Xin Li Qianxue Yu Aisha Bushi Jinxiang Yuan Rubin Tan |
| author_facet | Yue Shi Joseph Adu-Amankwaah Qizhong Zhao Xin Li Qianxue Yu Aisha Bushi Jinxiang Yuan Rubin Tan |
| author_sort | Yue Shi |
| collection | DOAJ |
| description | Cancer drug resistance stands as a formidable obstacle in the relentless fight against the top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for a significant portion of cancer-related deaths worldwide. In recent years, long non-coding RNAs (lncRNAs) have emerged as pivotal players in the intricate landscape of cancer biology, and their roles in driving drug resistance are steadily coming to light. This comprehensive review seeks to underscore the paramount significance of lncRNAs in orchestrating resistance across a spectrum of different cancer drugs, including platinum drugs (DDP), tamoxifen, trastuzumab, 5-fluorouracil (5-FU), paclitaxel (PTX), and Androgen Deprivation Therapy (ADT) across the most prevalent types of cancer. It delves into the multifaceted mechanisms through which lncRNAs exert their influence on drug resistance, shedding light on their regulatory roles in various facets of cancer biology. A comprehensive understanding of these lncRNA-mediated mechanisms may pave the way for more effective and personalized treatment strategies, ultimately improving patient outcomes in these challenging malignancies. |
| first_indexed | 2024-03-07T14:01:23Z |
| format | Article |
| id | doaj.art-b34022d040f642db87275a7ba825982c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:14:07Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b34022d040f642db87275a7ba825982c2024-03-17T07:57:39ZengElsevierHeliyon2405-84402024-03-01105e27207Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanismsYue Shi0Joseph Adu-Amankwaah1Qizhong Zhao2Xin Li3Qianxue Yu4Aisha Bushi5Jinxiang Yuan6Rubin Tan7Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou, ChinaDepartment of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou, ChinaDepartment of Emergency, The First Hospital of China Medical University, Shenyang, ChinaClinical Medical College, Jining Medical University, 272067, Jining, China; Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, 272067, Jining, ChinaClinical Medical College, Jining Medical University, 272067, Jining, China; Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, 272067, Jining, ChinaSchool of International Education, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, ChinaCollaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, 272067, Jining, China; Lin He's Academician Workstation of New Medicine and Clinical Translation, Jining Medical University, 272067, Jining, China; Corresponding author. Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, 272067, Jining, China.Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou, China; Corresponding author.Cancer drug resistance stands as a formidable obstacle in the relentless fight against the top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for a significant portion of cancer-related deaths worldwide. In recent years, long non-coding RNAs (lncRNAs) have emerged as pivotal players in the intricate landscape of cancer biology, and their roles in driving drug resistance are steadily coming to light. This comprehensive review seeks to underscore the paramount significance of lncRNAs in orchestrating resistance across a spectrum of different cancer drugs, including platinum drugs (DDP), tamoxifen, trastuzumab, 5-fluorouracil (5-FU), paclitaxel (PTX), and Androgen Deprivation Therapy (ADT) across the most prevalent types of cancer. It delves into the multifaceted mechanisms through which lncRNAs exert their influence on drug resistance, shedding light on their regulatory roles in various facets of cancer biology. A comprehensive understanding of these lncRNA-mediated mechanisms may pave the way for more effective and personalized treatment strategies, ultimately improving patient outcomes in these challenging malignancies.http://www.sciencedirect.com/science/article/pii/S2405844024032389lncRNAsCancerDrug resistanceChemoresistanceCancer therapy resistance |
| spellingShingle | Yue Shi Joseph Adu-Amankwaah Qizhong Zhao Xin Li Qianxue Yu Aisha Bushi Jinxiang Yuan Rubin Tan Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms Heliyon lncRNAs Cancer Drug resistance Chemoresistance Cancer therapy resistance |
| title | Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms |
| title_full | Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms |
| title_fullStr | Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms |
| title_full_unstemmed | Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms |
| title_short | Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms |
| title_sort | long non coding rnas in drug resistance across the top five cancers update on their roles and mechanisms |
| topic | lncRNAs Cancer Drug resistance Chemoresistance Cancer therapy resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024032389 |
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