Distress andneoangiogenesis in ovarian cancer patients
Background. Previous pre-clinical and clinical trials showed that distress experienced by cancer patients can activate the sympathetic nervous system, resulting in the elevation of the level of catecholamines in tumor tissue. catecholamines activate tumor neoangiogenesis via binding to the adrenergi...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2019-04-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1010 |
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| author | G. P. Guens I. N. Oleynikova N. A. Sirota N. I. Moiseeva V. E. Shikina V. V. Kirkin |
| author_facet | G. P. Guens I. N. Oleynikova N. A. Sirota N. I. Moiseeva V. E. Shikina V. V. Kirkin |
| author_sort | G. P. Guens |
| collection | DOAJ |
| description | Background. Previous pre-clinical and clinical trials showed that distress experienced by cancer patients can activate the sympathetic nervous system, resulting in the elevation of the level of catecholamines in tumor tissue. catecholamines activate tumor neoangiogenesis via binding to the adrenergic receptors of tumor cells and cells of tumor microenvironment. Vascular endothelial growth factor a(VEgF a) plays a key role in tumor neoangiogenesis.Objective. To evaluate the correlation between serum VEgF alevel and distress in ovarian cancer patients.Material and methods. The prospective cross-sectional study included 100 patients with stage i–iV ovarian cancer. the median age of the patients was 56 ± 9,56 years. Enzym-linked immunosorbent assay was used for the assessment of serum VEgF alevel. distress thermometer (validated self-reported questionnaire) was used for distress diagnosis.Results. The median serum VEgF alevel was 325.77 pg/ml. aclinically significant distress was diagnosed in 54 % of patients. We found the correlation between the serum VEgF alevel and distress level in ovarian cancer patients (spearman’s rho=0.33; 95 % ci, 0.11–0.52; р< 0.004). We also found the correlation between the serum VEgR alevel and disease stage (rho=0.30; 95 % ci0.02–0.53; p<0.05). However, there was no correlation between distress and disease stage. the regression analysis method revealed that distress was an independent factor of serum VEgF aelevation in ovarian cancer patients (p<0.05).Conclusion. Assessment and early diagnosis of cancer-related distress was shown to be important for the appropriate management of ovarian cancer. |
| first_indexed | 2024-04-10T01:53:35Z |
| format | Article |
| id | doaj.art-b341722e04944840bd5f795fd97e27c8 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:08:48Z |
| publishDate | 2019-04-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-b341722e04944840bd5f795fd97e27c82025-03-02T11:16:11ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-04-01182222710.21294/1814-4861-2019-18-2-22-27622Distress andneoangiogenesis in ovarian cancer patientsG. P. Guens0I. N. Oleynikova1N. A. Sirota2N. I. Moiseeva3V. E. Shikina4V. V. Kirkin5A.I. Yevdokimov Moscow State University of Medicine and Dentistry.A.I. Yevdokimov Moscow State University of Medicine and Dentistry.A.I. Yevdokimov Moscow State University of Medicine and Dentistry.N.N. Blokhin National Medical Research Center of Oncology.Federal Medical and Biology Agency.N.A. Semashko Central Clinical Hospital №2 of Russian Railway Company.Background. Previous pre-clinical and clinical trials showed that distress experienced by cancer patients can activate the sympathetic nervous system, resulting in the elevation of the level of catecholamines in tumor tissue. catecholamines activate tumor neoangiogenesis via binding to the adrenergic receptors of tumor cells and cells of tumor microenvironment. Vascular endothelial growth factor a(VEgF a) plays a key role in tumor neoangiogenesis.Objective. To evaluate the correlation between serum VEgF alevel and distress in ovarian cancer patients.Material and methods. The prospective cross-sectional study included 100 patients with stage i–iV ovarian cancer. the median age of the patients was 56 ± 9,56 years. Enzym-linked immunosorbent assay was used for the assessment of serum VEgF alevel. distress thermometer (validated self-reported questionnaire) was used for distress diagnosis.Results. The median serum VEgF alevel was 325.77 pg/ml. aclinically significant distress was diagnosed in 54 % of patients. We found the correlation between the serum VEgF alevel and distress level in ovarian cancer patients (spearman’s rho=0.33; 95 % ci, 0.11–0.52; р< 0.004). We also found the correlation between the serum VEgR alevel and disease stage (rho=0.30; 95 % ci0.02–0.53; p<0.05). However, there was no correlation between distress and disease stage. the regression analysis method revealed that distress was an independent factor of serum VEgF aelevation in ovarian cancer patients (p<0.05).Conclusion. Assessment and early diagnosis of cancer-related distress was shown to be important for the appropriate management of ovarian cancer.https://www.siboncoj.ru/jour/article/view/1010ovarian cancerdistressneoangiogenesisvascular endothelial growth factor apsycho-oncologyquality of life |
| spellingShingle | G. P. Guens I. N. Oleynikova N. A. Sirota N. I. Moiseeva V. E. Shikina V. V. Kirkin Distress andneoangiogenesis in ovarian cancer patients Сибирский онкологический журнал ovarian cancer distress neoangiogenesis vascular endothelial growth factor a psycho-oncology quality of life |
| title | Distress andneoangiogenesis in ovarian cancer patients |
| title_full | Distress andneoangiogenesis in ovarian cancer patients |
| title_fullStr | Distress andneoangiogenesis in ovarian cancer patients |
| title_full_unstemmed | Distress andneoangiogenesis in ovarian cancer patients |
| title_short | Distress andneoangiogenesis in ovarian cancer patients |
| title_sort | distress andneoangiogenesis in ovarian cancer patients |
| topic | ovarian cancer distress neoangiogenesis vascular endothelial growth factor a psycho-oncology quality of life |
| url | https://www.siboncoj.ru/jour/article/view/1010 |
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