Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

Bibliográfalaš dieđut
Váldodahkkit:	Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Materiálatiipa:	Artihkal
Giella:	English
Almmustuhtton:	Public Library of Science (PLoS) 2014-01-01
Ráidu:	PLoS ONE
Liŋkkat:	http://europepmc.org/articles/PMC3946503?pdf=render

Geahča maid

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation
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Almmustuhtton: (2017-06-01)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
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Almmustuhtton: (2021-08-01)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
Dahkki: Klindert, S
Almmustuhtton: (2023)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
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Almmustuhtton: (2016-06-01)

Identification of a potent antagonist of smoothened in hedgehog signaling
Dahkki: Junwan Fan, et al.
Almmustuhtton: (2021-03-01)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
Dahkki: Nachtergaele, S, et al.
Almmustuhtton: (2013)

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
Dahkki: Yongbin Chen, et al.
Almmustuhtton: (2011-06-01)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
Dahkki: Rohatgi, Rajat, et al.
Almmustuhtton: (2014)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
Dahkki: Zhao, Zhonghua, et al.
Almmustuhtton: (2016)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
Dahkki: Sigrid Nachtergaele, et al.
Almmustuhtton: (2013-10-01)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
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Almmustuhtton: (2021-09-01)

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
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Almmustuhtton: (2010-12-01)

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Almmustuhtton: (2002-11-01)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
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Almmustuhtton: (2019-01-01)

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
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Almmustuhtton: (2011-11-01)

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
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Almmustuhtton: (2017)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
Dahkki: Byrne, E
Almmustuhtton: (2017)

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Dahkki: Shuang Li, et al.
Almmustuhtton: (2012-01-01)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
Dahkki: Giovanni Luchetti, et al.
Almmustuhtton: (2016-10-01)

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling.
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Almmustuhtton: (2013-01-01)

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
Dahkki: Bomi Jung, et al.
Almmustuhtton: (2016-01-01)

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
Dahkki: Corvin D Arveseth, et al.
Almmustuhtton: (2021-04-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
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Almmustuhtton: (2018-12-01)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
Dahkki: Kowatsch, C, et al.
Almmustuhtton: (2019)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
Dahkki: Woolley, R
Almmustuhtton: (2021)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
Dahkki: Madison F Walker, et al.
Almmustuhtton: (2024-08-01)

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
Dahkki: Bingchen Han, et al.
Almmustuhtton: (2015-11-01)

Cilia-associated oxysterols activate Smoothened
Dahkki: Raleigh, DR, et al.
Almmustuhtton: (2018)

Linear and nonlinear approach for DEM smoothening
Dahkki: S. Dinesh, et al.
Almmustuhtton: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
Almmustuhtton: (2006-01-01)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
Dahkki: Silvia Pietrobono, et al.
Almmustuhtton: (2019-06-01)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
Dahkki: Fecher LA, et al.
Almmustuhtton: (2015-11-01)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
Dahkki: Wang J, et al.
Almmustuhtton: (2024-11-01)

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
Dahkki: Shuangxi Li, et al.
Almmustuhtton: (2016-06-01)

A Smoothening Method for the Piecewise Linear Interpolation
Dahkki: Beong In Yun
Almmustuhtton: (2015-01-01)

Structural basis for Smoothened regulation by its extracellular domains
Dahkki: Siebold, C, et al.
Almmustuhtton: (2016)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
Dahkki: Shoujun Huang, et al.
Almmustuhtton: (2013-11-01)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
Dahkki: Marina Gonçalves Antunes, et al.
Almmustuhtton: (2022-09-01)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
Dahkki: Twigg, S, et al.
Almmustuhtton: (2016)

Possible solution to smoothen the torque curve of the CAMPRO engine
Dahkki: Mohiuddin, A. K. M., et al.
Almmustuhtton: (2011)