Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Public Library of Science (PLoS) 2014-01-01
Σειρά:PLoS ONE
Διαθέσιμο Online:http://europepmc.org/articles/PMC3946503?pdf=render

Διαδίκτυο

http://europepmc.org/articles/PMC3946503?pdf=render

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