Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats
Background and Objectives: Studies have shown that changes in the serum levels of sex hormones can influence thyroid gland function. The purpose of this study was to investigate the effect of decreased testosterone after orchidectomy on the serum level of thyroid hormones in male rats. Methods: I...
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2017-07-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
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| Online Access: | http://journal.muq.ac.ir/browse.php?a_code=A-10-567-1&slc_lang=en&sid=1 |
| _version_ | 1818715710968299520 |
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| author | Rahim Ahmadi Sedigheh Molaee |
| author_facet | Rahim Ahmadi Sedigheh Molaee |
| author_sort | Rahim Ahmadi |
| collection | DOAJ |
| description | Background and Objectives: Studies have shown that changes in the serum levels of sex hormones can influence thyroid gland function. The purpose of this study was to investigate the effect of decreased testosterone after orchidectomy on the serum level of thyroid hormones in male rats.
Methods: In this laboratory experimental study, Wistar rats were divided into 7-animal groups, including control, sham, unilateral orchidectomized, and bilateral orchidectomized. After 10 weeks, blood samples were collected using cardiac puncture method and serum levels of T3, T4, and TSH, testosterone, and DHEA, were measured. Data were analyzed using one-way ANOVA statistical test.
Results: Serum testosterone level significantly decreased in orchidectomized (unilateral and bilateral) rats compared to the control group (p<0.001). Serum level of DHEA significantly decreased in bilateral orchidectomized rats compared to the control group (p<0.05). In the bilateral orchidectomized rats, serum level of T3 had a significant increase compared to the control group (p<0.05), but serum levels of TSH and T4 was not significantly changed.
Conclusion: Findings of this study indicated that considerable decrease in serum level of testosterone results in increased level of serum T3, and accordingly, decreased level of serum testosterone leads to disorders caused by increased serum T3. |
| first_indexed | 2024-12-17T19:07:42Z |
| format | Article |
| id | doaj.art-b345050448f94b6793f7bf802378fe60 |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-17T19:07:42Z |
| publishDate | 2017-07-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-b345050448f94b6793f7bf802378fe602022-12-21T21:35:58ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752017-07-0111518Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male RatsRahim Ahmadi0Sedigheh Molaee1 Department of Physiology, Faculty of Basic Sciences, Hamadan Branch, Islamic Azad University, Hamadan, Iran. Student Research Committee, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran. Background and Objectives: Studies have shown that changes in the serum levels of sex hormones can influence thyroid gland function. The purpose of this study was to investigate the effect of decreased testosterone after orchidectomy on the serum level of thyroid hormones in male rats. Methods: In this laboratory experimental study, Wistar rats were divided into 7-animal groups, including control, sham, unilateral orchidectomized, and bilateral orchidectomized. After 10 weeks, blood samples were collected using cardiac puncture method and serum levels of T3, T4, and TSH, testosterone, and DHEA, were measured. Data were analyzed using one-way ANOVA statistical test. Results: Serum testosterone level significantly decreased in orchidectomized (unilateral and bilateral) rats compared to the control group (p<0.001). Serum level of DHEA significantly decreased in bilateral orchidectomized rats compared to the control group (p<0.05). In the bilateral orchidectomized rats, serum level of T3 had a significant increase compared to the control group (p<0.05), but serum levels of TSH and T4 was not significantly changed. Conclusion: Findings of this study indicated that considerable decrease in serum level of testosterone results in increased level of serum T3, and accordingly, decreased level of serum testosterone leads to disorders caused by increased serum T3.http://journal.muq.ac.ir/browse.php?a_code=A-10-567-1&slc_lang=en&sid=1orchidectomy testosterone dehydroepiandrosterone triiodothyronine t4 ths rats. |
| spellingShingle | Rahim Ahmadi Sedigheh Molaee Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum orchidectomy testosterone dehydroepiandrosterone triiodothyronine t4 ths rats. |
| title | Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats |
| title_full | Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats |
| title_fullStr | Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats |
| title_full_unstemmed | Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats |
| title_short | Investigation of the Effects of Orchidectomy on Serum Levels of TSH, T3, and T4 in Male Rats |
| title_sort | investigation of the effects of orchidectomy on serum levels of tsh t3 and t4 in male rats |
| topic | orchidectomy testosterone dehydroepiandrosterone triiodothyronine t4 ths rats. |
| url | http://journal.muq.ac.ir/browse.php?a_code=A-10-567-1&slc_lang=en&sid=1 |
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