Altered network topologies and hub organization in adults with autism: a resting-state fMRI study.
Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functiona...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3979738?pdf=render |
| _version_ | 1819096156289892352 |
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| author | Takashi Itahashi Takashi Yamada Hiromi Watanabe Motoaki Nakamura Daiki Jimbo Seiji Shioda Kazuo Toriizuka Nobumasa Kato Ryuichiro Hashimoto |
| author_facet | Takashi Itahashi Takashi Yamada Hiromi Watanabe Motoaki Nakamura Daiki Jimbo Seiji Shioda Kazuo Toriizuka Nobumasa Kato Ryuichiro Hashimoto |
| author_sort | Takashi Itahashi |
| collection | DOAJ |
| description | Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functional connectivity in the adult ASC brain, such functional alterations at the network level have not yet been fully characterized within the recently developed graph-theoretical framework. Here, we applied a graph-theoretical analysis to resting-state fMRI data acquired from 46 adults with ASC and 46 age- and gender-matched controls, to investigate the topological properties and organization of autistic brain network. Analyses of global metrics revealed that, relative to the controls, participants with ASC exhibited significant decreases in clustering coefficient and characteristic path length, indicating a shift towards randomized organization. Furthermore, analyses of local metrics revealed a significantly altered organization of the hub nodes in ASC, as shown by analyses of hub disruption indices using multiple local metrics and by a loss of "hubness" in several nodes (e.g., the bilateral superior temporal sulcus, right dorsolateral prefrontal cortex, and precuneus) that are critical for social and non-social cognitive functions. In particular, local metrics of the anterior cingulate cortex consistently showed significant negative correlations with the Autism-Spectrum Quotient score. Our results demonstrate altered patterns of global and local topological properties that may underlie impaired social and non-social cognition in ASC. |
| first_indexed | 2024-12-21T23:54:43Z |
| format | Article |
| id | doaj.art-b345a4f6ca374c9e8add4def512831f2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T23:54:43Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b345a4f6ca374c9e8add4def512831f22022-12-21T18:45:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9411510.1371/journal.pone.0094115Altered network topologies and hub organization in adults with autism: a resting-state fMRI study.Takashi ItahashiTakashi YamadaHiromi WatanabeMotoaki NakamuraDaiki JimboSeiji ShiodaKazuo ToriizukaNobumasa KatoRyuichiro HashimotoRecent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved in social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI studies have revealed atypical functional connectivity in the adult ASC brain, such functional alterations at the network level have not yet been fully characterized within the recently developed graph-theoretical framework. Here, we applied a graph-theoretical analysis to resting-state fMRI data acquired from 46 adults with ASC and 46 age- and gender-matched controls, to investigate the topological properties and organization of autistic brain network. Analyses of global metrics revealed that, relative to the controls, participants with ASC exhibited significant decreases in clustering coefficient and characteristic path length, indicating a shift towards randomized organization. Furthermore, analyses of local metrics revealed a significantly altered organization of the hub nodes in ASC, as shown by analyses of hub disruption indices using multiple local metrics and by a loss of "hubness" in several nodes (e.g., the bilateral superior temporal sulcus, right dorsolateral prefrontal cortex, and precuneus) that are critical for social and non-social cognitive functions. In particular, local metrics of the anterior cingulate cortex consistently showed significant negative correlations with the Autism-Spectrum Quotient score. Our results demonstrate altered patterns of global and local topological properties that may underlie impaired social and non-social cognition in ASC.http://europepmc.org/articles/PMC3979738?pdf=render |
| spellingShingle | Takashi Itahashi Takashi Yamada Hiromi Watanabe Motoaki Nakamura Daiki Jimbo Seiji Shioda Kazuo Toriizuka Nobumasa Kato Ryuichiro Hashimoto Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. PLoS ONE |
| title | Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. |
| title_full | Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. |
| title_fullStr | Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. |
| title_full_unstemmed | Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. |
| title_short | Altered network topologies and hub organization in adults with autism: a resting-state fMRI study. |
| title_sort | altered network topologies and hub organization in adults with autism a resting state fmri study |
| url | http://europepmc.org/articles/PMC3979738?pdf=render |
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