Inflammatory markers in children with obstructive sleep apnea syndrome
ObjectiveTo evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS.MethodsThe ELISA technique has been used to identify the concentration of inflam...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1134678/full |
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| author | Yingge Wang Yingge Wang Yingge Wang Ying Chen Wei Lin Wei Lin Wei Lin Min Huang Min Huang Min Huang Yuanteng Xu Yuanteng Xu Yuanteng Xu Guohao Chen Guohao Chen Guohao Chen |
| author_facet | Yingge Wang Yingge Wang Yingge Wang Ying Chen Wei Lin Wei Lin Wei Lin Min Huang Min Huang Min Huang Yuanteng Xu Yuanteng Xu Yuanteng Xu Guohao Chen Guohao Chen Guohao Chen |
| author_sort | Yingge Wang |
| collection | DOAJ |
| description | ObjectiveTo evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS.MethodsThe ELISA technique has been used to identify the concentration of inflammatory markers such as YKL-40, IL-6, IL-8, IL-10, TNF-α, and CRP in the serum of 83 children with OSAS and 83 children without OSAS.ResultsSerum levels of YKL-40, IL-6, IL-8, and IL-10 were found to be increased in children with OSAS. YKL-40 was found to be positively correlated with IL-6 and IL-8, and negatively correlated with IL-10. At the same time,YKL-40 was also found to be positively correlated with OAHI and LoSpO2% in OSAS group. IL-8 was positively correlated with OAHI whereas IL-10 was positively correlated with LoSpO2.ConclusionChildren with OSAS are in a systemic inflammatory state. YKL-40 together with IL-8 may act as serum inflammatory markers and provide an indication for the diagnosis of children with OSAS. |
| first_indexed | 2024-04-09T18:36:37Z |
| format | Article |
| id | doaj.art-b3467d0404164562812a214a5e5b68b0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-09T18:36:37Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-b3467d0404164562812a214a5e5b68b02023-04-11T10:07:56ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-04-011110.3389/fped.2023.11346781134678Inflammatory markers in children with obstructive sleep apnea syndromeYingge Wang0Yingge Wang1Yingge Wang2Ying Chen3Wei Lin4Wei Lin5Wei Lin6Min Huang7Min Huang8Min Huang9Yuanteng Xu10Yuanteng Xu11Yuanteng Xu12Guohao Chen13Guohao Chen14Guohao Chen15Department of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaThe Second Affiliated Hospital of Xiamen Medical College, Xiaman, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Sleep Medicine Center, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaFujian Institute of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaObjectiveTo evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS.MethodsThe ELISA technique has been used to identify the concentration of inflammatory markers such as YKL-40, IL-6, IL-8, IL-10, TNF-α, and CRP in the serum of 83 children with OSAS and 83 children without OSAS.ResultsSerum levels of YKL-40, IL-6, IL-8, and IL-10 were found to be increased in children with OSAS. YKL-40 was found to be positively correlated with IL-6 and IL-8, and negatively correlated with IL-10. At the same time,YKL-40 was also found to be positively correlated with OAHI and LoSpO2% in OSAS group. IL-8 was positively correlated with OAHI whereas IL-10 was positively correlated with LoSpO2.ConclusionChildren with OSAS are in a systemic inflammatory state. YKL-40 together with IL-8 may act as serum inflammatory markers and provide an indication for the diagnosis of children with OSAS.https://www.frontiersin.org/articles/10.3389/fped.2023.1134678/fullYKL-40inflammatory factorsinterleukinOSA (Obstructive sleep apnea)obstructive sleep apnea syndrome |
| spellingShingle | Yingge Wang Yingge Wang Yingge Wang Ying Chen Wei Lin Wei Lin Wei Lin Min Huang Min Huang Min Huang Yuanteng Xu Yuanteng Xu Yuanteng Xu Guohao Chen Guohao Chen Guohao Chen Inflammatory markers in children with obstructive sleep apnea syndrome Frontiers in Pediatrics YKL-40 inflammatory factors interleukin OSA (Obstructive sleep apnea) obstructive sleep apnea syndrome |
| title | Inflammatory markers in children with obstructive sleep apnea syndrome |
| title_full | Inflammatory markers in children with obstructive sleep apnea syndrome |
| title_fullStr | Inflammatory markers in children with obstructive sleep apnea syndrome |
| title_full_unstemmed | Inflammatory markers in children with obstructive sleep apnea syndrome |
| title_short | Inflammatory markers in children with obstructive sleep apnea syndrome |
| title_sort | inflammatory markers in children with obstructive sleep apnea syndrome |
| topic | YKL-40 inflammatory factors interleukin OSA (Obstructive sleep apnea) obstructive sleep apnea syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1134678/full |
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