Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection
Despite efficient virological suppression on antiretroviral therapy (ART), people living with HIV (PLWH), experience an increased burden of premature co-morbidities, such as cancer and end-organ disease. With remaining challenges in terms of access to therapy, adherence and potential long-term drug...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00395/full |
| _version_ | 1819158764847104000 |
|---|---|
| author | Aljawharah Alrubayyi Ane Ogbe Elia Moreno Cubero Dimitra Peppa Dimitra Peppa |
| author_facet | Aljawharah Alrubayyi Ane Ogbe Elia Moreno Cubero Dimitra Peppa Dimitra Peppa |
| author_sort | Aljawharah Alrubayyi |
| collection | DOAJ |
| description | Despite efficient virological suppression on antiretroviral therapy (ART), people living with HIV (PLWH), experience an increased burden of premature co-morbidities, such as cancer and end-organ disease. With remaining challenges in terms of access to therapy, adherence and potential long-term drug toxicity, improving their long-term healthcare outcome, including new strategies for HIV clearance, remains a global priority. There is, therefore, an ongoing need to better characterize and harness the immune response in order to develop new strategies and supplement current therapeutic approaches for a “functional” cure. Current efforts toward HIV eradication to enhance immune recognition and elimination of persistently infected cells have highlighted the need for an optimized “kill” approach. Natural killer (NK) cells play an important role in antiviral defense and by virtue of their innate and adaptive features hold great promise as a focus of “kill” efforts. Galvanized by advances in the cancer field, NK cell exploitation, represents a transformative approach to augment HIV therapeutic modalities, circumventing many of the limitations inherent to T cell approaches. In this review we will discuss recent advances in our understanding of the development of NK cell adaptive/memory responses in HIV infection and highlight new and exciting opportunities to exploit the beneficial attributes of NK cells for HIV immunotherapy. |
| first_indexed | 2024-12-22T16:29:51Z |
| format | Article |
| id | doaj.art-b34723b197d647768c6b95cdd426c905 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T16:29:51Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b34723b197d647768c6b95cdd426c9052022-12-21T18:20:05ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-08-011010.3389/fcimb.2020.00395539811Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV InfectionAljawharah Alrubayyi0Ane Ogbe1Elia Moreno Cubero2Dimitra Peppa3Dimitra Peppa4Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United KingdomPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomNuffield Department of Clinical Medicine, University of Oxford, Oxford, United KingdomNuffield Department of Clinical Medicine, University of Oxford, Oxford, United KingdomDepartment of HIV, Mortimer Market Centre, CNWL NHS Trust, London, OH, United KingdomDespite efficient virological suppression on antiretroviral therapy (ART), people living with HIV (PLWH), experience an increased burden of premature co-morbidities, such as cancer and end-organ disease. With remaining challenges in terms of access to therapy, adherence and potential long-term drug toxicity, improving their long-term healthcare outcome, including new strategies for HIV clearance, remains a global priority. There is, therefore, an ongoing need to better characterize and harness the immune response in order to develop new strategies and supplement current therapeutic approaches for a “functional” cure. Current efforts toward HIV eradication to enhance immune recognition and elimination of persistently infected cells have highlighted the need for an optimized “kill” approach. Natural killer (NK) cells play an important role in antiviral defense and by virtue of their innate and adaptive features hold great promise as a focus of “kill” efforts. Galvanized by advances in the cancer field, NK cell exploitation, represents a transformative approach to augment HIV therapeutic modalities, circumventing many of the limitations inherent to T cell approaches. In this review we will discuss recent advances in our understanding of the development of NK cell adaptive/memory responses in HIV infection and highlight new and exciting opportunities to exploit the beneficial attributes of NK cells for HIV immunotherapy.https://www.frontiersin.org/article/10.3389/fcimb.2020.00395/fullnatural killer (NK) cellshuman immunodeficiency virus (HIV)cytomegalovirus (CMV)adaptive NK cellsimmunotherapy |
| spellingShingle | Aljawharah Alrubayyi Ane Ogbe Elia Moreno Cubero Dimitra Peppa Dimitra Peppa Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection Frontiers in Cellular and Infection Microbiology natural killer (NK) cells human immunodeficiency virus (HIV) cytomegalovirus (CMV) adaptive NK cells immunotherapy |
| title | Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection |
| title_full | Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection |
| title_fullStr | Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection |
| title_full_unstemmed | Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection |
| title_short | Harnessing Natural Killer Cell Innate and Adaptive Traits in HIV Infection |
| title_sort | harnessing natural killer cell innate and adaptive traits in hiv infection |
| topic | natural killer (NK) cells human immunodeficiency virus (HIV) cytomegalovirus (CMV) adaptive NK cells immunotherapy |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00395/full |
| work_keys_str_mv | AT aljawharahalrubayyi harnessingnaturalkillercellinnateandadaptivetraitsinhivinfection AT aneogbe harnessingnaturalkillercellinnateandadaptivetraitsinhivinfection AT eliamorenocubero harnessingnaturalkillercellinnateandadaptivetraitsinhivinfection AT dimitrapeppa harnessingnaturalkillercellinnateandadaptivetraitsinhivinfection AT dimitrapeppa harnessingnaturalkillercellinnateandadaptivetraitsinhivinfection |