Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson’s Disease: Synaptic Pathology and Neuronal Aging

The motor and nonmotor symptoms of PD involve several brain regions. However, whether α-syn pathology originating from the SNc can directly lead to the pathological changes in distant cerebral regions and induce PD-related symptoms remains unclear. Here, AAV9-synapsin-mCherry-human SNCA (A53T) was i...

Celý popis

Podrobná bibliografie
Hlavní autoři: Qing-Jun Wang, An-Di Chen, Hai-Chao Chen, Dong-Xin Wang, Yi-Ting Cai, Jie Yin, Yu-Hong Jing, Li-Ping Gao
Médium: Článek
Jazyk:English
Vydáno: Wiley 2020-01-01
Edice:Neural Plasticity
On-line přístup:http://dx.doi.org/10.1155/2020/6283754