How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis?
<b>Aim:</b> Recently, the most commonly used for multiple breath washout device, the Exhalyzer D, has been shown to overestimate lung clearance index (LCI) results due to a software error. Our study aimed to compare the predictive values of LCI in the CF pulmonary exacerbations (PE) calc...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/14/2336 |
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| author | Irena Wojsyk-Banaszak Zuzanna Stachowiak Barbara Więckowska Marta Andrzejewska Katarzyna Tąpolska-Jóźwiak Aleksandra Szczepankiewicz Paulina Sobkowiak Anna Bręborowicz |
| author_facet | Irena Wojsyk-Banaszak Zuzanna Stachowiak Barbara Więckowska Marta Andrzejewska Katarzyna Tąpolska-Jóźwiak Aleksandra Szczepankiewicz Paulina Sobkowiak Anna Bręborowicz |
| author_sort | Irena Wojsyk-Banaszak |
| collection | DOAJ |
| description | <b>Aim:</b> Recently, the most commonly used for multiple breath washout device, the Exhalyzer D, has been shown to overestimate lung clearance index (LCI) results due to a software error. Our study aimed to compare the predictive values of LCI in the CF pulmonary exacerbations (PE) calculated with the updated (3.3.1) and the previous (3.2.1) version of the Spiroware software. <b>Materials and Methods:</b> The measurements were performed during 259 visits in CF pediatric patients. We used 39ΔPE pairs (PE preceded by stable visit) and 138ΔS pairs (stable visit preceded by stable visit) to compare the LCI changes during PE. The areas under the receiver operating curves (AUC<sup>ROC</sup>) and odds ratios were calculated based on the differences between ΔPEs and ΔSs. The exacerbation risk was estimated using a logistic regression model with generalized estimating equations (GEE). <b>Results:</b> There were statistically significant differences in LCI 2.5% median values measured using the two versions of the software in the stable condition but not during PE. The AUC<sup>ROC</sup> for changes between the two consecutive visits for LCI did not change significantly using the updated Spiroware software. <b>Conclusions:</b> Despite the lower median values, using the recalculated LCI values does not influence the diagnostic accuracy of this parameter in CF PE. |
| first_indexed | 2024-03-11T01:09:59Z |
| format | Article |
| id | doaj.art-b34b449a689b4db0a47a0ac4015a9efa |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:09:59Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-b34b449a689b4db0a47a0ac4015a9efa2023-11-18T18:57:15ZengMDPI AGDiagnostics2075-44182023-07-011314233610.3390/diagnostics13142336How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis?Irena Wojsyk-Banaszak0Zuzanna Stachowiak1Barbara Więckowska2Marta Andrzejewska3Katarzyna Tąpolska-Jóźwiak4Aleksandra Szczepankiewicz5Paulina Sobkowiak6Anna Bręborowicz7Department of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandMolecular and Cell Biology Unit, Department of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandMolecular and Cell Biology Unit, Department of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, PolandDepartment of Paediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, 60-572 Poznan, Poland<b>Aim:</b> Recently, the most commonly used for multiple breath washout device, the Exhalyzer D, has been shown to overestimate lung clearance index (LCI) results due to a software error. Our study aimed to compare the predictive values of LCI in the CF pulmonary exacerbations (PE) calculated with the updated (3.3.1) and the previous (3.2.1) version of the Spiroware software. <b>Materials and Methods:</b> The measurements were performed during 259 visits in CF pediatric patients. We used 39ΔPE pairs (PE preceded by stable visit) and 138ΔS pairs (stable visit preceded by stable visit) to compare the LCI changes during PE. The areas under the receiver operating curves (AUC<sup>ROC</sup>) and odds ratios were calculated based on the differences between ΔPEs and ΔSs. The exacerbation risk was estimated using a logistic regression model with generalized estimating equations (GEE). <b>Results:</b> There were statistically significant differences in LCI 2.5% median values measured using the two versions of the software in the stable condition but not during PE. The AUC<sup>ROC</sup> for changes between the two consecutive visits for LCI did not change significantly using the updated Spiroware software. <b>Conclusions:</b> Despite the lower median values, using the recalculated LCI values does not influence the diagnostic accuracy of this parameter in CF PE.https://www.mdpi.com/2075-4418/13/14/2336multiple breath washoutLCIcystic fibrosischildren |
| spellingShingle | Irena Wojsyk-Banaszak Zuzanna Stachowiak Barbara Więckowska Marta Andrzejewska Katarzyna Tąpolska-Jóźwiak Aleksandra Szczepankiewicz Paulina Sobkowiak Anna Bręborowicz How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? Diagnostics multiple breath washout LCI cystic fibrosis children |
| title | How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? |
| title_full | How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? |
| title_fullStr | How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? |
| title_full_unstemmed | How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? |
| title_short | How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? |
| title_sort | how does the corrected exhalyzer software change the predictive value of lci in pulmonary exacerbations in children with cystic fibrosis |
| topic | multiple breath washout LCI cystic fibrosis children |
| url | https://www.mdpi.com/2075-4418/13/14/2336 |
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