The expressed mutational landscape of microsatellite stable colorectal cancers

The expressed mutational landscape of microsatellite stable colorectal cancers

Abstract Background Colorectal cancer is the 2nd leading cause of cancer-related deaths with few patients benefiting from biomarker-guided therapy. Mutation expression is essential for accurate interpretation of mutations as biomarkers, but surprisingly, little has been done to analyze somatic cance...

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Main Authors: Anita Sveen, Bjarne Johannessen, Ina A. Eilertsen, Bård I. Røsok, Marie Gulla, Peter W. Eide, Jarle Bruun, Kushtrim Kryeziu, Leonardo A. Meza-Zepeda, Ola Myklebost, Bjørn A. Bjørnbeth, Rolf I. Skotheim, Arild Nesbakken, Ragnhild A. Lothe
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Genome Medicine
Subjects:
Colorectal cancer
Exome sequencing
RNA sequencing
Allele-specific mutation expression
Mutant allele fraction
Pharmacogenomics
Online Access:https://doi.org/10.1186/s13073-021-00955-2

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