Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate
Photodynamic therapy (PDT) has been increasingly used in the clinical treatment of neoplastic, inflammatory and infectious skin diseases. However, the generation of reactive oxygen species (ROS) may induce undesired side effects in normal tissue surrounding the treatment lesion, which is a big chall...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2024-05-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S1793545824500020 |
| _version_ | 1797216853701951488 |
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| author | Tianlong Chen Yi Shen Li Lin Huiyun Lin Xuejiao Song Defu Chen Buhong Li |
| author_facet | Tianlong Chen Yi Shen Li Lin Huiyun Lin Xuejiao Song Defu Chen Buhong Li |
| author_sort | Tianlong Chen |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) has been increasingly used in the clinical treatment of neoplastic, inflammatory and infectious skin diseases. However, the generation of reactive oxygen species (ROS) may induce undesired side effects in normal tissue surrounding the treatment lesion, which is a big challenge for the clinical application of PDT. To date, (–)-Epigallocatechin gallate (EGCG) has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage. This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether (Hemoporfin)-mediated PDT. The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be [Formula: see text] M−1S−1 and [Formula: see text] M−1S−1, respectively. The vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel, suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with EGCG. This study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2, and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT. |
| first_indexed | 2024-04-24T11:52:34Z |
| format | Article |
| id | doaj.art-b34bb8e2faad4d27a2b44590a272ca6b |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-24T11:52:34Z |
| publishDate | 2024-05-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-b34bb8e2faad4d27a2b44590a272ca6b2024-04-09T07:13:16ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052024-05-01170310.1142/S1793545824500020Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallateTianlong Chen0Yi Shen1Li Lin2Huiyun Lin3Xuejiao Song4Defu Chen5Buhong Li6MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, P. R. ChinaMOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, P. R. ChinaMOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, P. R. ChinaMOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, P. R. ChinaKey Laboratory of Flexible Electronics and Institute of Advanced Materials, Nanjing Technology University, Nanjing 211800, P. R. ChinaSchool of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. ChinaMOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou 350117, P. R. ChinaPhotodynamic therapy (PDT) has been increasingly used in the clinical treatment of neoplastic, inflammatory and infectious skin diseases. However, the generation of reactive oxygen species (ROS) may induce undesired side effects in normal tissue surrounding the treatment lesion, which is a big challenge for the clinical application of PDT. To date, (–)-Epigallocatechin gallate (EGCG) has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage. This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether (Hemoporfin)-mediated PDT. The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be [Formula: see text] M−1S−1 and [Formula: see text] M−1S−1, respectively. The vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel, suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with EGCG. This study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2, and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.https://www.worldscientific.com/doi/10.1142/S1793545824500020(–)-Epigallocatechin gallate (EGCG)photodynamic therapyhemoporfinsinglet oxygenblood vesselvasoconstriction |
| spellingShingle | Tianlong Chen Yi Shen Li Lin Huiyun Lin Xuejiao Song Defu Chen Buhong Li Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate Journal of Innovative Optical Health Sciences (–)-Epigallocatechin gallate (EGCG) photodynamic therapy hemoporfin singlet oxygen blood vessel vasoconstriction |
| title | Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate |
| title_full | Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate |
| title_fullStr | Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate |
| title_full_unstemmed | Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate |
| title_short | Reduction of photodynamic damage of blood vessels in the protected region by (–)-epigallocatechin gallate |
| title_sort | reduction of photodynamic damage of blood vessels in the protected region by epigallocatechin gallate |
| topic | (–)-Epigallocatechin gallate (EGCG) photodynamic therapy hemoporfin singlet oxygen blood vessel vasoconstriction |
| url | https://www.worldscientific.com/doi/10.1142/S1793545824500020 |
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