The tuber extract and flour of Dioscorea alatanormalize the blood lipid profile of rabbits treated with high cholesterol diets
Abstrak<br />Latar belakang: Umbi Dioscorea alata (DA) memiliki potensi untuk mencegah kondisi hiperlipidemia karena mengandung senyawa bioaktif antosianin, serat pangan, dan diosgenin yang bermanfaat dalam <br />menormalkan kadar lipida darah. Pada penelitian ini dipelajari pengaruh pem...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Badan Penelitian dan Pengembangan Kesehatan
2014-08-01
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| Series: | Health Science Journal of Indonesia |
| Subjects: | |
| Online Access: | http://ejournal.litbang.depkes.go.id/index.php/HSJI/article/view/3527 |
| Summary: | Abstrak<br />Latar belakang: Umbi Dioscorea alata (DA) memiliki potensi untuk mencegah kondisi hiperlipidemia karena mengandung senyawa bioaktif antosianin, serat pangan, dan diosgenin yang bermanfaat dalam <br />menormalkan kadar lipida darah. Pada penelitian ini dipelajari pengaruh pemberian ekstrak air dan tepung umbi DA dalam menormalkan profil lipida darah kelinci yang diberi ransum tinggi kolesterol.<br />Metode: Ekstrak dan tepung umbi DA diberikan kepada kelinci percobaan selama 60 hari dengan disain penelitian rancangan acak lengkap. Perlakuan ransum sebagai berikut: 1) Ransum basal sebagai kontrol <br />negatif (K0), 2) Ransum basal + kolesterol 0.5% sebagai kontrol positif (K1), 3) Ransum basal+kolesterol 0.5% + ekstrak DA 1.8 g/100 g (KE1), 4) Ransum basal+kolesterol 0.5%+ekstrak DA 3.6 g/100 g (KE2), <br />5) Ransum basal mengandung 15% tepung DA + kolesterol 0.5% (KT1) dan 6) Ransum basal mengandung 30% tepung DA + kolesterol 0.5% (KT2). Kadar total kolesterol, LDL, HDL kolesterol dan trigliserida <br />pada serum dianalisa pada awal, hari ke 28, hari ke 56 dan pada akhir penelitian. <br />Hasil: Pemberian ransum tinggi kolesterol sebanyak 1% meningkatkan kadar kolesterol darah sebesar 16 kali dibandingkan kontrol. Pemberian 15% dan 30% tepung DA ransum tinggi kolesterol dapat mempertahakankan profil lipida darah kelinci ke arah normal, khususnya pada substitusi 30% tepung DA. Akan tetapi, ekstrak air tepung DA tidak dapat mempertahankan kadar lipida normal kelinci yang diberi ransum tinggi kolesterol. <br />Kesimpulan:Tepung DA memiliki efek anti-hiperlipidemia. (Health Science Indones 2014;1:23-9)<br />Kata kunci:ekstrak, tepung, Dioscorea alata, hiperlipidemia<br /><br />Abstract<br />Background: Dioscorea alata(DA) tuber has potential to prevent the condition of hyperlipidemia due to the bioactive compound, such as anthocyanins, diosgenin, and dietary fiber that beneficial in normalizing <br />blood lipid profiles. In this research, the effect of water extract and flour of DA tuber administration was examined on rabbits treated with high cholesterol diets.<br />Methods:DA tuber extract and flour were administrated to the rabbits for 60 days using completely randomised design. The ration treatment are as follows: 1) Basal ration as negative control (K0), 2) Basal ration + 0.5% cholesterol, as positive control (K1), 3) Basal ration + 0.5% cholesterol + DA extract 1.8 g/100 g (KE1), 4) Basal ration + cholesterol 0.5% + DA extract 3.6 g/100 g (KE2), 5) Basal ration with 15% DA flour + 0.5% cholesterol (KT1) and 6) Basal ration with 30% DA flour + 0.5% cholesterol (KT2). The Total cholesterol, HDL, LDL cholesterol in serum were analysed at baseline, days 28, days 56 and at the end of study.<br />Results:The administration of high cholesterol (1%) ration increased blood lipid levels by 16 fold compared to that of control. The administration of 15% and 30% of DA flour could maintain blood lipid profile to normal condition, in particular at 30% substitution DA flour. However the water extract of DA can not maintain a normal blood lipids of high cholesterol treated rabbits<br />Conclusion: Dioscorea alata flour has suggested to have anti-hyperlipidemia effect. (Health Science Indones 2014;1:23-9)<br />Key words: Dioscorea alata, hyperlipidemia, atherosclerosis |
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| ISSN: | 2087-7021 2338-3437 |