Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase

Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase

Despite the well-known relevance of polyamines to many forms of life, little is known about how polyamines regulate osteogenesis and skeletal homeostasis. Here, we report a series of in vitro studies conducted with human-bone-marrow-derived pluripotent stromal cells (MSCs). First, we show that durin...

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Bibliographic Details
Main Authors: Amin Cressman, David Morales, Zhenyang Zhang, Bryan Le, Jackson Foley, Tracy Murray-Stewart, Damian C. Genetos, Fernando A. Fierro
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
MSCs
spermine synthase
polyamines
osteogenesis
Snyder–Robinson syndrome
Online Access:https://www.mdpi.com/1422-0067/25/5/2463

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