Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i>
Cell size is a critical factor for cell cycle regulation. In <i>Xenopus</i> embryos after midblastula transition, the cell cycle duration elongates in a power law relationship with the cell radius squared. This correlation has been explained by the model that cell surface area is a candi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00529/full |
| _version_ | 1818525321683533824 |
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| author | Yukinobu eArata Hiroaki eTakagi Yasushi eSako Hitoshi eSawa |
| author_facet | Yukinobu eArata Hiroaki eTakagi Yasushi eSako Hitoshi eSawa |
| author_sort | Yukinobu eArata |
| collection | DOAJ |
| description | Cell size is a critical factor for cell cycle regulation. In <i>Xenopus</i> embryos after midblastula transition, the cell cycle duration elongates in a power law relationship with the cell radius squared. This correlation has been explained by the model that cell surface area is a candidate to determine cell cycle duration. However, it remains unknown whether this second power law is conserved in other animal embryos. Here, we found that the relationship between cell cycle duration and cell size in <i>Caenorhabditis elegans</i> embryos exhibited a power law distribution. Interestingly, the powers of the time-size relationship could be grouped into at least three classes: highly size-correlated, moderately size-correlated, and potentially a size-noncorrelated class according to <i>C. elegans</i> founder cell lineages (1.2, 0.81, and <0.39 in radius, respectively). Thus, the power law relationship is conserved in <i>Xenopus</i> and <i>C. elegans</i>, while the absolute powers in <i>C. elegans</i> were different from that in <i>Xenopus</i>. Furthermore, we found that the volume ratio between the nucleus and cell exhibited a power law relationship in the size-correlated classes. The power of the volume relationship was closest to that of the time-size relationship in the highly size-correlated class. This correlation raised the possibility that the time-size relationship, at least in the highly size-correlated class, is explained by the volume ratio of nuclear size and cell size. Thus, our quantitative measurements shed a light on the possibility that early embryonic <i>C. elegans</i> cell cycle duration is coordinated with cell size as a result of geometric constraints between intracellular structures. |
| first_indexed | 2024-12-11T06:07:53Z |
| format | Article |
| id | doaj.art-b34cba6c1e2f4423ba006b12e390262c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T06:07:53Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b34cba6c1e2f4423ba006b12e390262c2022-12-22T01:18:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-01-01510.3389/fphys.2014.00529117299Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i>Yukinobu eArata0Hiroaki eTakagi1Yasushi eSako2Hitoshi eSawa3RikenSchool of Medicine, Nara Medical University, Nara, JapanRikenNational Institute of GeneticsCell size is a critical factor for cell cycle regulation. In <i>Xenopus</i> embryos after midblastula transition, the cell cycle duration elongates in a power law relationship with the cell radius squared. This correlation has been explained by the model that cell surface area is a candidate to determine cell cycle duration. However, it remains unknown whether this second power law is conserved in other animal embryos. Here, we found that the relationship between cell cycle duration and cell size in <i>Caenorhabditis elegans</i> embryos exhibited a power law distribution. Interestingly, the powers of the time-size relationship could be grouped into at least three classes: highly size-correlated, moderately size-correlated, and potentially a size-noncorrelated class according to <i>C. elegans</i> founder cell lineages (1.2, 0.81, and <0.39 in radius, respectively). Thus, the power law relationship is conserved in <i>Xenopus</i> and <i>C. elegans</i>, while the absolute powers in <i>C. elegans</i> were different from that in <i>Xenopus</i>. Furthermore, we found that the volume ratio between the nucleus and cell exhibited a power law relationship in the size-correlated classes. The power of the volume relationship was closest to that of the time-size relationship in the highly size-correlated class. This correlation raised the possibility that the time-size relationship, at least in the highly size-correlated class, is explained by the volume ratio of nuclear size and cell size. Thus, our quantitative measurements shed a light on the possibility that early embryonic <i>C. elegans</i> cell cycle duration is coordinated with cell size as a result of geometric constraints between intracellular structures.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00529/fullcell volumepower lawcell cycle durationnuclear-cytoplasmic volume ratioima-3/Importin α |
| spellingShingle | Yukinobu eArata Hiroaki eTakagi Yasushi eSako Hitoshi eSawa Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> Frontiers in Physiology cell volume power law cell cycle duration nuclear-cytoplasmic volume ratio ima-3/Importin α |
| title | Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> |
| title_full | Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> |
| title_fullStr | Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> |
| title_short | Power law relationship between cell cycle duration and cell volume in the early embryonic development of <i>Caenorhabditis elegans</i> |
| title_sort | power law relationship between cell cycle duration and cell volume in the early embryonic development of lt i gt caenorhabditis elegans lt i gt |
| topic | cell volume power law cell cycle duration nuclear-cytoplasmic volume ratio ima-3/Importin α |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00529/full |
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