Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine
The management of osteosarcoma (OS) patients presents a significant clinical challenge. Despite progress in conventional and targeted therapies, the survival rate of OS patients remains limited largely due to therapy resistance and the high metastatic potential of the disease. OS models that accurat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/9/1362 |
| _version_ | 1797581118836310016 |
|---|---|
| author | Linyun Tan Yitian Wang Xin Hu Guifeng Du Xiaodi Tang Li Min |
| author_facet | Linyun Tan Yitian Wang Xin Hu Guifeng Du Xiaodi Tang Li Min |
| author_sort | Linyun Tan |
| collection | DOAJ |
| description | The management of osteosarcoma (OS) patients presents a significant clinical challenge. Despite progress in conventional and targeted therapies, the survival rate of OS patients remains limited largely due to therapy resistance and the high metastatic potential of the disease. OS models that accurately reflect the fundamental characteristics are vital to the innovation and validation of effective therapies. This review provides an insight into the advances and challenges in OS drug development, focusing on various preclinical models, including cell lines, 3D culture models, murine models, and canine models. The relevance, strengths, and limitations of each model in OS research are explored. In particular, we highlight a range of potential therapeutics identified through these models. These instances of successful drug development represent promising pathways for personalized OS treatment. |
| first_indexed | 2024-03-10T22:59:38Z |
| format | Article |
| id | doaj.art-b34df9e9d0ff49a19dbc9f55935d4afc |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T22:59:38Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b34df9e9d0ff49a19dbc9f55935d4afc2023-11-19T09:45:57ZengMDPI AGBiomolecules2218-273X2023-09-01139136210.3390/biom13091362Advances of Osteosarcoma Models for Drug Discovery and Precision MedicineLinyun Tan0Yitian Wang1Xin Hu2Guifeng Du3Xiaodi Tang4Li Min5Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, ChinaThe management of osteosarcoma (OS) patients presents a significant clinical challenge. Despite progress in conventional and targeted therapies, the survival rate of OS patients remains limited largely due to therapy resistance and the high metastatic potential of the disease. OS models that accurately reflect the fundamental characteristics are vital to the innovation and validation of effective therapies. This review provides an insight into the advances and challenges in OS drug development, focusing on various preclinical models, including cell lines, 3D culture models, murine models, and canine models. The relevance, strengths, and limitations of each model in OS research are explored. In particular, we highlight a range of potential therapeutics identified through these models. These instances of successful drug development represent promising pathways for personalized OS treatment.https://www.mdpi.com/2218-273X/13/9/1362osteosarcoma modelscell lines3D culture technologymice modelscanine modelsdrug discovery |
| spellingShingle | Linyun Tan Yitian Wang Xin Hu Guifeng Du Xiaodi Tang Li Min Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine Biomolecules osteosarcoma models cell lines 3D culture technology mice models canine models drug discovery |
| title | Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine |
| title_full | Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine |
| title_fullStr | Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine |
| title_full_unstemmed | Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine |
| title_short | Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine |
| title_sort | advances of osteosarcoma models for drug discovery and precision medicine |
| topic | osteosarcoma models cell lines 3D culture technology mice models canine models drug discovery |
| url | https://www.mdpi.com/2218-273X/13/9/1362 |
| work_keys_str_mv | AT linyuntan advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine AT yitianwang advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine AT xinhu advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine AT guifengdu advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine AT xiaoditang advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine AT limin advancesofosteosarcomamodelsfordrugdiscoveryandprecisionmedicine |