Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model ge...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-11-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00834/full |
| _version_ | 1818111304608514048 |
|---|---|
| author | Jin-Jing Jia Jin-Jing Jia Jin-Jing Jia Xian-Si Zeng Xian-Si Zeng Xian-Si Zeng Xin-Qiang Song Peng-Peng Zhang Lei Chen |
| author_facet | Jin-Jing Jia Jin-Jing Jia Jin-Jing Jia Xian-Si Zeng Xian-Si Zeng Xian-Si Zeng Xin-Qiang Song Peng-Peng Zhang Lei Chen |
| author_sort | Jin-Jing Jia |
| collection | DOAJ |
| description | Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD. |
| first_indexed | 2024-12-11T03:00:55Z |
| format | Article |
| id | doaj.art-b34e3e59039d43b682cd63b5f748cd2f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T03:00:55Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b34e3e59039d43b682cd63b5f748cd2f2022-12-22T01:23:03ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-11-01810.3389/fphar.2017.00834319273Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced ModelsJin-Jing Jia0Jin-Jing Jia1Jin-Jing Jia2Xian-Si Zeng3Xian-Si Zeng4Xian-Si Zeng5Xin-Qiang Song6Peng-Peng Zhang7Lei Chen8College of Life Sciences, Xinyang Normal University, Xinyang, ChinaInstitute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, ChinaHenan Key Laboratory of Tea Biology, Xinyang Normal University, Xinyang, ChinaCollege of Life Sciences, Xinyang Normal University, Xinyang, ChinaInstitute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, ChinaHenan Key Laboratory of Tea Biology, Xinyang Normal University, Xinyang, ChinaCollege of Life Sciences, Xinyang Normal University, Xinyang, ChinaCollege of Life Sciences, Xinyang Normal University, Xinyang, ChinaCollege of Life Sciences, Xinyang Normal University, Xinyang, ChinaDiabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD.http://journal.frontiersin.org/article/10.3389/fphar.2017.00834/fulldiabetesAlzheimer’s diseasestreptozotocinepigallocatechin-3-gallateprotection |
| spellingShingle | Jin-Jing Jia Jin-Jing Jia Jin-Jing Jia Xian-Si Zeng Xian-Si Zeng Xian-Si Zeng Xin-Qiang Song Peng-Peng Zhang Lei Chen Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models Frontiers in Pharmacology diabetes Alzheimer’s disease streptozotocin epigallocatechin-3-gallate protection |
| title | Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| title_full | Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| title_fullStr | Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| title_full_unstemmed | Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| title_short | Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models |
| title_sort | diabetes mellitus and alzheimer s disease the protection of epigallocatechin 3 gallate in streptozotocin injection induced models |
| topic | diabetes Alzheimer’s disease streptozotocin epigallocatechin-3-gallate protection |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00834/full |
| work_keys_str_mv | AT jinjingjia diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT jinjingjia diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT jinjingjia diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT xiansizeng diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT xiansizeng diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT xiansizeng diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT xinqiangsong diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT pengpengzhang diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels AT leichen diabetesmellitusandalzheimersdiseasetheprotectionofepigallocatechin3gallateinstreptozotocininjectioninducedmodels |