Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis
In recent years, scientific researchers have increasingly become interested in noninvasive sampling methods for therapeutic drug monitoring and disease diagnosis. As a result, dried saliva spot (DSS), which is a sampling technique for collecting dried saliva samples, has been widely used as an alter...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Pharmaceutical Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177921001192 |
| _version_ | 1797978783008948224 |
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| author | Yu Han Xi-Ling Li Minghui Zhang Jing Wang Su Zeng Jun Zhe Min |
| author_facet | Yu Han Xi-Ling Li Minghui Zhang Jing Wang Su Zeng Jun Zhe Min |
| author_sort | Yu Han |
| collection | DOAJ |
| description | In recent years, scientific researchers have increasingly become interested in noninvasive sampling methods for therapeutic drug monitoring and disease diagnosis. As a result, dried saliva spot (DSS), which is a sampling technique for collecting dried saliva samples, has been widely used as an alternative matrix to serum for the detection of target molecules. Coupling the DSS method with a highly sensitive detection instrument improves the efficiency of the preparation and analysis of biological samples. Furthermore, dried blood spots, dried plasma spots, and dried matrix spots, which are similar to those of the DSS method, are discussed. Compared with alternative biological fluids used in dried spot methods, including serum, tears, urine, and plasma, saliva has the advantage of convenience in terms of sample collection from children or persons with disabilities. This review aims to provide integral strategies and guidelines for dried spot methods to analyze biological samples by illustrating several dried spot methods. Herein, we summarize recent advancements in DSS methods from June 2014 to March 2021 and discuss the advantages and disadvantages of the key aspects of this method, including sample preparation and method validation. Finally, we outline the challenges and prospects of such methods in practical applications. |
| first_indexed | 2024-04-11T05:28:31Z |
| format | Article |
| id | doaj.art-b34e723338054cb2b2ccad1b3ee98561 |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-04-11T05:28:31Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-b34e723338054cb2b2ccad1b3ee985612022-12-23T04:40:42ZengElsevierJournal of Pharmaceutical Analysis2095-17792022-12-01126815823Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosisYu Han0Xi-Ling Li1Minghui Zhang2Jing Wang3Su Zeng4Jun Zhe Min5Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, ChinaKey Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, ChinaInstitute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; Corresponding author.Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Department of Pharmaceutical Analysis, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China; Corresponding author.In recent years, scientific researchers have increasingly become interested in noninvasive sampling methods for therapeutic drug monitoring and disease diagnosis. As a result, dried saliva spot (DSS), which is a sampling technique for collecting dried saliva samples, has been widely used as an alternative matrix to serum for the detection of target molecules. Coupling the DSS method with a highly sensitive detection instrument improves the efficiency of the preparation and analysis of biological samples. Furthermore, dried blood spots, dried plasma spots, and dried matrix spots, which are similar to those of the DSS method, are discussed. Compared with alternative biological fluids used in dried spot methods, including serum, tears, urine, and plasma, saliva has the advantage of convenience in terms of sample collection from children or persons with disabilities. This review aims to provide integral strategies and guidelines for dried spot methods to analyze biological samples by illustrating several dried spot methods. Herein, we summarize recent advancements in DSS methods from June 2014 to March 2021 and discuss the advantages and disadvantages of the key aspects of this method, including sample preparation and method validation. Finally, we outline the challenges and prospects of such methods in practical applications.http://www.sciencedirect.com/science/article/pii/S2095177921001192Human salivaDried saliva spotTherapeutic drug monitoringDisease diagnosis |
| spellingShingle | Yu Han Xi-Ling Li Minghui Zhang Jing Wang Su Zeng Jun Zhe Min Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis Journal of Pharmaceutical Analysis Human saliva Dried saliva spot Therapeutic drug monitoring Disease diagnosis |
| title | Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis |
| title_full | Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis |
| title_fullStr | Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis |
| title_full_unstemmed | Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis |
| title_short | Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis |
| title_sort | potential use of a dried saliva spot dss in therapeutic drug monitoring and disease diagnosis |
| topic | Human saliva Dried saliva spot Therapeutic drug monitoring Disease diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S2095177921001192 |
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