Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease
Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer’s disease (AD) models and human AD brain, and that the...
Main Authors: | Michael JD Daniels, Lucas Lefevre, Stefan Szymkowiak, Alice Drake, Laura McCulloch, Makis Tzioras, Jack Barrington, Owen R Dando, Xin He, Mehreen Mohammad, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Tara L Spires-Jones, Barry W McColl |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/85279 |
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