Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI

Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI

Human amniotic mesenchymal stem cells (hAMSCs) were previously shown to effectively rescue ovarian function in a premature ovarian insufficiency (POI) mouse model. The therapeutic mechanism of hAMSC-derived exosomes (hAMSC-Exos) is not fully understood. In this study, the therapeutic mechanism invol...

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Bibliographic Details
Main Authors: Chenyue Ding, Chunfeng Qian, Shunyu Hou, Jiafeng Lu, Qinyan Zou, Hong Li, Boxian Huang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
human amniotic mesenchymal stem cells
exosomes
miR-320a
SIRT4
premature ovarian insufficiency
oxidative stres
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301396

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http://www.sciencedirect.com/science/article/pii/S2162253120301396

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