Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite
Hydrogels are ideal biomaterials owing to their unique network structure that facilitates considerable hydrophilicity and biocompatibility. At the same time, hydrogels also possess soft physical properties when combined with living tissue. In this study, metformin hydrogen chloride (metformin HC...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2020-07-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | https://ijtech.eng.ui.ac.id/article/view/2330 |
| _version_ | 1797968300500582400 |
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| author | Dhena Ria Barleany Claudia Vivi Ananta Fistia Maulina Agus Rochmat Hafid Alwan Erizal |
| author_facet | Dhena Ria Barleany Claudia Vivi Ananta Fistia Maulina Agus Rochmat Hafid Alwan Erizal |
| author_sort | Dhena Ria Barleany |
| collection | DOAJ |
| description | Hydrogels are ideal biomaterials owing to
their unique network structure that facilitates considerable hydrophilicity and
biocompatibility. At the same time, hydrogels also possess soft physical
properties when combined with living tissue. In this study, metformin hydrogen
chloride (metformin HCl)-loaded stimuli-responsive poly(N-isopropylacrylamide)
(pNIPAAm) –chitosan–polyvinyl alcohol (PVA)
hydrogels were synthesized through a freezing and thawing procedure and
subsequently subjected to gamma irradiation at room temperature. The gel
content and the water absorption capacity of the synthesized hydrogels were
analyzed. The polymer interaction
in the matrix was observed by Fourier transform infrared
spectroscopy, and the release of metformin HCl was
studied in different pHs and temperatures. The hydrogels had 85% of the gel
content and 373% of the water absorption capacity after 24 h of water
immersion. The metformin HCl-loaded (pNIPAAm–chitosan–PVA) hydrogels demonstrated a sustained drug release profile over 7 h.
The drug release exhibited pH-dependent and temperature-dependent behavior. The
developed hydrogels showed good metformin HCl release ability at pH 3 and pH
6.86 at the temperature of 37oC. The results showed that pNIPAAm–chitosan–PVA hydrogels could be employed for controlled drug
release of metformin HCl. |
| first_indexed | 2024-04-11T02:44:42Z |
| format | Article |
| id | doaj.art-b3513e73109e4af3b559bea85493e052 |
| institution | Directory Open Access Journal |
| issn | 2086-9614 2087-2100 |
| language | English |
| last_indexed | 2024-04-11T02:44:42Z |
| publishDate | 2020-07-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | International Journal of Technology |
| spelling | doaj.art-b3513e73109e4af3b559bea85493e0522023-01-02T18:21:30ZengUniversitas IndonesiaInternational Journal of Technology2086-96142087-21002020-07-0111351152110.14716/ijtech.v11i3.23302330Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol CompositeDhena Ria Barleany0Claudia Vivi Ananta1Fistia Maulina2Agus Rochmat3Hafid Alwan4Erizal5Departement of Chemical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Jl. Jend. Sudirman Km. 03, Cilegon, Banten 42435, IndonesiaDepartement of Chemical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Jl. Jend. Sudirman Km. 03, Cilegon, Banten 42435, IndonesiaDepartement of Chemical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Jl. Jend. Sudirman Km. 03, Cilegon, Banten 42435, IndonesiaDepartement of Chemical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Jl. Jend. Sudirman Km. 03, Cilegon, Banten 42435, IndonesiaDepartement of Chemical Engineering, Faculty of Engineering, University of Sultan Ageng Tirtayasa, Jl. Jend. Sudirman Km. 03, Cilegon, Banten 42435, IndonesiaCentre for Application of Isotopes and Radiation, South Jakarta 7002, IndonesiaHydrogels are ideal biomaterials owing to their unique network structure that facilitates considerable hydrophilicity and biocompatibility. At the same time, hydrogels also possess soft physical properties when combined with living tissue. In this study, metformin hydrogen chloride (metformin HCl)-loaded stimuli-responsive poly(N-isopropylacrylamide) (pNIPAAm) –chitosan–polyvinyl alcohol (PVA) hydrogels were synthesized through a freezing and thawing procedure and subsequently subjected to gamma irradiation at room temperature. The gel content and the water absorption capacity of the synthesized hydrogels were analyzed. The polymer interaction in the matrix was observed by Fourier transform infrared spectroscopy, and the release of metformin HCl was studied in different pHs and temperatures. The hydrogels had 85% of the gel content and 373% of the water absorption capacity after 24 h of water immersion. The metformin HCl-loaded (pNIPAAm–chitosan–PVA) hydrogels demonstrated a sustained drug release profile over 7 h. The drug release exhibited pH-dependent and temperature-dependent behavior. The developed hydrogels showed good metformin HCl release ability at pH 3 and pH 6.86 at the temperature of 37oC. The results showed that pNIPAAm–chitosan–PVA hydrogels could be employed for controlled drug release of metformin HCl.https://ijtech.eng.ui.ac.id/article/view/2330controlled drug releasehydrogelmetformin hcl |
| spellingShingle | Dhena Ria Barleany Claudia Vivi Ananta Fistia Maulina Agus Rochmat Hafid Alwan Erizal Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite International Journal of Technology controlled drug release hydrogel metformin hcl |
| title | Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite |
| title_full | Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite |
| title_fullStr | Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite |
| title_full_unstemmed | Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite |
| title_short | Controlled Release of Metformin Hydrogen Chloride from Stimuli-responsive Hydrogel based on Poly(N- Isopropylacrylamide)/Chitosan/Polyvinyl Alcohol Composite |
| title_sort | controlled release of metformin hydrogen chloride from stimuli responsive hydrogel based on poly n isopropylacrylamide chitosan polyvinyl alcohol composite |
| topic | controlled drug release hydrogel metformin hcl |
| url | https://ijtech.eng.ui.ac.id/article/view/2330 |
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