Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments

Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myeloid leukemia (AML) remains a challenge despite the development of novel FLT3-directed tyrosine kinase inhibitors (TKI); the relapse rate is still high even after allogeneic stem cell transplantation....

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Bibliographic Details
Main Authors: Sebastian Scholl, Maximilian Fleischmann, Ulf Schnetzke, Florian H. Heidel
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
acute myeloid leukemia
AML
FMS-like tyrosine kinase 3
FLT3
FLT3-ITD
FLT3-TKD
Online Access:https://www.mdpi.com/2073-4409/9/11/2493

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