Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice.

Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice.

BACKGROUND:Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previous studies have shown a correlation between β-cell...

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Main Authors: Manishkumar Patel, Alexa Gleason, Stacey O'Malley, Brett Connolly, Donna Suresch, John Virostko, Neil Phillips, Shu-An Lin, Tsing-Bau Chen, Michael Klimas, Richard J Hargreaves, Cyrille Sur, David L Williams, Alvin C Powers, Bohumil Bednar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4157804?pdf=render

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