Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women
Objectives: To access the lipid profiles and its association with pre-eclampsia and eclampsia in nulliparous pregnant women. Material and Methods: This cross-sectional study was performed on 234 nulliparous pregnant women with gestation period of > 20 weeks and aged 15-45 years, from March t...
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| Format: | Article |
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Rawalpindi Medical University
2022-03-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1690 |
| _version_ | 1811192285086351360 |
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| author | Asmat Shaheen Muhammad Waqas Luqman Syed Fahim Shah Fozia Zeb Atta Ullah Khan Zahoor Ahmed |
| author_facet | Asmat Shaheen Muhammad Waqas Luqman Syed Fahim Shah Fozia Zeb Atta Ullah Khan Zahoor Ahmed |
| author_sort | Asmat Shaheen |
| collection | DOAJ |
| description |
Objectives: To access the lipid profiles and its association with pre-eclampsia and eclampsia in nulliparous pregnant women.
Material and Methods: This cross-sectional study was performed on 234 nulliparous pregnant women with gestation period of > 20 weeks and aged 15-45 years, from March to October 2014, in Institute of Basic Medical Sciences (IBMS), Khyber Medical University (KMU), Peshawar, Pakistan with cooperation from gynecology and obstetrics departments of three tertiary-care hospitals of Peshawar & Khyber Medical College, Peshawar, Khyber Pakhtunkhwa (KP), Pakistan. Subjects were assigned to three groups i.e., group A, group B and group C. For performing biochemical assays and lipid profiling, through ELISA, blood samples were collected from already subjects both with the disease and the controls.
Results: Both subjects having pre-eclampsia and eclampsia showed significant elevated levels (p < 0.001) for low density lipoproteins cholesterols (LDL-c), high density lipoprotein cholesterol (HDL-c), total cholesterol (TC)/HDL-c and LDL-c/HDL-c ratio. But TC of pre-eclampsia subjects were found significantly elevated (p < 0.001) in relation to controls. LDL-c/HDL-c and TC/HDL-c also revealed an elevated significant change (p < 0.001) both for pre-eclamptic and eclamptic subjects. On the other hand, only TG/HDL-c in pre-eclamptic patients was found significantly higher (p<0.004) when compared to control group.
Conclusion: Serum lipid levels were observed higher in pre-eclampsia and eclampsia patients hence an early assessment is necessary to prevent complications in such patients.
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| first_indexed | 2024-04-11T23:50:04Z |
| format | Article |
| id | doaj.art-b3527c82bc3b47c8b3c60a859ec908fe |
| institution | Directory Open Access Journal |
| issn | 1683-3562 1683-3570 |
| language | English |
| last_indexed | 2024-04-11T23:50:04Z |
| publishDate | 2022-03-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj.art-b3527c82bc3b47c8b3c60a859ec908fe2022-12-22T03:56:30ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702022-03-0126110.37939/jrmc.v26i1.1690Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant WomenAsmat ShaheenMuhammad Waqas LuqmanSyed Fahim ShahFozia ZebAtta Ullah KhanZahoor Ahmed Objectives: To access the lipid profiles and its association with pre-eclampsia and eclampsia in nulliparous pregnant women. Material and Methods: This cross-sectional study was performed on 234 nulliparous pregnant women with gestation period of > 20 weeks and aged 15-45 years, from March to October 2014, in Institute of Basic Medical Sciences (IBMS), Khyber Medical University (KMU), Peshawar, Pakistan with cooperation from gynecology and obstetrics departments of three tertiary-care hospitals of Peshawar & Khyber Medical College, Peshawar, Khyber Pakhtunkhwa (KP), Pakistan. Subjects were assigned to three groups i.e., group A, group B and group C. For performing biochemical assays and lipid profiling, through ELISA, blood samples were collected from already subjects both with the disease and the controls. Results: Both subjects having pre-eclampsia and eclampsia showed significant elevated levels (p < 0.001) for low density lipoproteins cholesterols (LDL-c), high density lipoprotein cholesterol (HDL-c), total cholesterol (TC)/HDL-c and LDL-c/HDL-c ratio. But TC of pre-eclampsia subjects were found significantly elevated (p < 0.001) in relation to controls. LDL-c/HDL-c and TC/HDL-c also revealed an elevated significant change (p < 0.001) both for pre-eclamptic and eclamptic subjects. On the other hand, only TG/HDL-c in pre-eclamptic patients was found significantly higher (p<0.004) when compared to control group. Conclusion: Serum lipid levels were observed higher in pre-eclampsia and eclampsia patients hence an early assessment is necessary to prevent complications in such patients. https://www.journalrmc.com/index.php/JRMC/article/view/1690Pre-eclampsia, Eclampsia, Lipid Profiling, Hypertension IBMS |
| spellingShingle | Asmat Shaheen Muhammad Waqas Luqman Syed Fahim Shah Fozia Zeb Atta Ullah Khan Zahoor Ahmed Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women Journal of Rawalpindi Medical College Pre-eclampsia, Eclampsia, Lipid Profiling, Hypertension IBMS |
| title | Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women |
| title_full | Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women |
| title_fullStr | Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women |
| title_full_unstemmed | Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women |
| title_short | Lipid Profiles and Its Association with Pre-Eclampsia and Eclampsia in Nulliparous Pregnant Women |
| title_sort | lipid profiles and its association with pre eclampsia and eclampsia in nulliparous pregnant women |
| topic | Pre-eclampsia, Eclampsia, Lipid Profiling, Hypertension IBMS |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1690 |
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