Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression
Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimula...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1267647/full |
| _version_ | 1797648821900017664 |
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| author | Weronika Dębowska Magdalena Więdłocha Marta Dębowska Zuzanna Kownacka Piotr Marcinowicz Agata Szulc |
| author_facet | Weronika Dębowska Magdalena Więdłocha Marta Dębowska Zuzanna Kownacka Piotr Marcinowicz Agata Szulc |
| author_sort | Weronika Dębowska |
| collection | DOAJ |
| description | Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols. |
| first_indexed | 2024-03-11T15:37:30Z |
| format | Article |
| id | doaj.art-b355321ba9a64fc4a588e838f3794b7b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-11T15:37:30Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b355321ba9a64fc4a588e838f3794b7b2023-10-26T14:37:20ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-10-011710.3389/fnins.2023.12676471267647Transcranial magnetic stimulation and ketamine: implications for combined treatment in depressionWeronika DębowskaMagdalena WiędłochaMarta DębowskaZuzanna KownackaPiotr MarcinowiczAgata SzulcDrug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols.https://www.frontiersin.org/articles/10.3389/fnins.2023.1267647/fulldepressive disorderstreatment-resistant depressiontranscranial magnetic stimulationTMSrTMSketamine |
| spellingShingle | Weronika Dębowska Magdalena Więdłocha Marta Dębowska Zuzanna Kownacka Piotr Marcinowicz Agata Szulc Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression Frontiers in Neuroscience depressive disorders treatment-resistant depression transcranial magnetic stimulation TMS rTMS ketamine |
| title | Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression |
| title_full | Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression |
| title_fullStr | Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression |
| title_full_unstemmed | Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression |
| title_short | Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression |
| title_sort | transcranial magnetic stimulation and ketamine implications for combined treatment in depression |
| topic | depressive disorders treatment-resistant depression transcranial magnetic stimulation TMS rTMS ketamine |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1267647/full |
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