Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues
Abstract All‐liquid molding can be used to transform a liquid into free‐form solid constructs, while maintaining internal fluidity. Traditional biological scaffolds, such as cured pre‐gels, are normally processed in solid state, sacrificing flowability and permeability. However, it is essential to m...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202300694 |
| _version_ | 1797692686093778944 |
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| author | Chao Luo Xubo Liu Yifan Zhang Haoyu Dai Hai Ci Shan Mou Muran Zhou Lifeng Chen Zhenxing Wang Thomas P. Russell Jiaming Sun |
| author_facet | Chao Luo Xubo Liu Yifan Zhang Haoyu Dai Hai Ci Shan Mou Muran Zhou Lifeng Chen Zhenxing Wang Thomas P. Russell Jiaming Sun |
| author_sort | Chao Luo |
| collection | DOAJ |
| description | Abstract All‐liquid molding can be used to transform a liquid into free‐form solid constructs, while maintaining internal fluidity. Traditional biological scaffolds, such as cured pre‐gels, are normally processed in solid state, sacrificing flowability and permeability. However, it is essential to maintain the fluidity of the scaffold to truly mimic the complexity and heterogeneity of natural human tissues. Here, this work molds an aqueous biomaterial ink into liquid building blocks with rigid shapes while preserving internal fluidity. The molded ink blocks for bone‐like vertebrae and cartilaginous‐intervertebral‐disc shapes, are magnetically manipulated to assemble into hierarchical structures as a scaffold for subsequent spinal column tissue growth. It is also possible to join separate ink blocks by interfacial coalescence, different from bridging solid blocks by interfacial fixation. Generally, aqueous biomaterial inks are molded into shapes with high fidelity by the interfacial jamming of alginate surfactants. The molded liquid blocks can be reconfigured using induced magnetic dipoles, that dictated the magnetic assembly behavior of liquid blocks. The implanted spinal column tissue exhibits a biocompatibility based on in vitro seeding and in vivo cultivating results, showing potential physiological function such as bending of the spinal column. |
| first_indexed | 2024-03-12T02:32:10Z |
| format | Article |
| id | doaj.art-b35559aeec4a4b4c8cfc3ba431deed4f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T02:32:10Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b35559aeec4a4b4c8cfc3ba431deed4f2023-09-05T07:49:09ZengWileyAdvanced Science2198-38442023-09-011025n/an/a10.1002/advs.202300694Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column TissuesChao Luo0Xubo Liu1Yifan Zhang2Haoyu Dai3Hai Ci4Shan Mou5Muran Zhou6Lifeng Chen7Zhenxing Wang8Thomas P. Russell9Jiaming Sun10Department of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaCAS Key Laboratory of Bio‐Inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaCAS Key Laboratory of Bio‐Inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaDepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaMaterials Sciences Division Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USADepartment of Plastic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022ChinaAbstract All‐liquid molding can be used to transform a liquid into free‐form solid constructs, while maintaining internal fluidity. Traditional biological scaffolds, such as cured pre‐gels, are normally processed in solid state, sacrificing flowability and permeability. However, it is essential to maintain the fluidity of the scaffold to truly mimic the complexity and heterogeneity of natural human tissues. Here, this work molds an aqueous biomaterial ink into liquid building blocks with rigid shapes while preserving internal fluidity. The molded ink blocks for bone‐like vertebrae and cartilaginous‐intervertebral‐disc shapes, are magnetically manipulated to assemble into hierarchical structures as a scaffold for subsequent spinal column tissue growth. It is also possible to join separate ink blocks by interfacial coalescence, different from bridging solid blocks by interfacial fixation. Generally, aqueous biomaterial inks are molded into shapes with high fidelity by the interfacial jamming of alginate surfactants. The molded liquid blocks can be reconfigured using induced magnetic dipoles, that dictated the magnetic assembly behavior of liquid blocks. The implanted spinal column tissue exhibits a biocompatibility based on in vitro seeding and in vivo cultivating results, showing potential physiological function such as bending of the spinal column.https://doi.org/10.1002/advs.202300694structured magnetic dropletsall‐liquid moldingalginate surfactantsspinal column structuresin vivo cultivated tissues |
| spellingShingle | Chao Luo Xubo Liu Yifan Zhang Haoyu Dai Hai Ci Shan Mou Muran Zhou Lifeng Chen Zhenxing Wang Thomas P. Russell Jiaming Sun Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues Advanced Science structured magnetic droplets all‐liquid molding alginate surfactants spinal column structures in vivo cultivated tissues |
| title | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues |
| title_full | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues |
| title_fullStr | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues |
| title_full_unstemmed | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues |
| title_short | Reconfigurable Magnetic Liquid Building Blocks for Constructing Artificial Spinal Column Tissues |
| title_sort | reconfigurable magnetic liquid building blocks for constructing artificial spinal column tissues |
| topic | structured magnetic droplets all‐liquid molding alginate surfactants spinal column structures in vivo cultivated tissues |
| url | https://doi.org/10.1002/advs.202300694 |
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