The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer
Background: Aldehyde dehydrogenase 1 (ALDH1) is an enzyme accountable for the detoxification of aldehydes. Sex-determining region Y-box 9 (SOX-9) plays a role in many biological and pathological processes. In this study, we aimed to evaluate the prognostic significance of ALDH1 and SOX9 expression i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-10-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | https://mejc.sums.ac.ir/article_48392_f4bf7679f66c34a01001b3bf295a94a7.pdf |
| _version_ | 1818022643281952768 |
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| author | Lobna Abdelaziz Ola Harb Abeer Abdelbary Amrallah Mohammed Hend Elkalla |
| author_facet | Lobna Abdelaziz Ola Harb Abeer Abdelbary Amrallah Mohammed Hend Elkalla |
| author_sort | Lobna Abdelaziz |
| collection | DOAJ |
| description | Background: Aldehyde dehydrogenase 1 (ALDH1) is an enzyme accountable for the detoxification of aldehydes. Sex-determining region Y-box 9 (SOX-9) plays a role in many biological and pathological processes. In this study, we aimed to evaluate the prognostic significance of ALDH1 and SOX9 expression in early breast cancer.
Method: The expression of ALDH1 and SOX-9 was evaluated through immunohistochemistry derived from 50 eligible patients with early breast cancer included in the current prospective cohort study.
Results: Positive expression of ALDH1 and SOX-9 were detected in 29 (58%) and 34 (68%) patients, respectively. The positive expressions of both markers were statistically significant associated with increasing the stage, lymph nodes metastasis, high Ki67 labeling index, and molecular subtypes (P < 0.001), along with with the biological markers; estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 over-expressions, and large tumor size (P = 0.039, P = 0.022, P = 0.024 and P = 0.003 for ALDH1 expression and P = 0.012, P = 0.007, P = 0.004 , and P = 0.002 for SOX-9 expression, respectively). There is a significant positive association between the expression of ALDH1 and SOX-9, r (correlation coefficient) = +0.806 (P < 0.001). Local recurrence was associated with the positive expression of ALDH1 only (P = 0.045) and the disease progression was statistically significant and associated with the positive expression of both ALDH1 and SOX-9 (P = 0.038, P = 0.023, respectively). There was significant association of positive expression of SOX-9 with reduced 3-y disease-free survival (P = 0.039).
Conclusion: Positive expression of ALDH-1 and SOX9 were associated with aggressive histopathological features and poor outcome in early breast cancer and can be considered potential prognostic markers in this group of patients. |
| first_indexed | 2024-12-10T03:31:41Z |
| format | Article |
| id | doaj.art-b356c827992a4069af28100e57f0a801 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-10T03:31:41Z |
| publishDate | 2022-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-b356c827992a4069af28100e57f0a8012022-12-22T02:03:48ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872022-10-0113458159210.30476/mejc.2022.90510.157848392The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast CancerLobna Abdelaziz0Ola Harb1Abeer Abdelbary2Amrallah Mohammed3Hend Elkalla4Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pathology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura, EgyptBackground: Aldehyde dehydrogenase 1 (ALDH1) is an enzyme accountable for the detoxification of aldehydes. Sex-determining region Y-box 9 (SOX-9) plays a role in many biological and pathological processes. In this study, we aimed to evaluate the prognostic significance of ALDH1 and SOX9 expression in early breast cancer. Method: The expression of ALDH1 and SOX-9 was evaluated through immunohistochemistry derived from 50 eligible patients with early breast cancer included in the current prospective cohort study. Results: Positive expression of ALDH1 and SOX-9 were detected in 29 (58%) and 34 (68%) patients, respectively. The positive expressions of both markers were statistically significant associated with increasing the stage, lymph nodes metastasis, high Ki67 labeling index, and molecular subtypes (P < 0.001), along with with the biological markers; estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 over-expressions, and large tumor size (P = 0.039, P = 0.022, P = 0.024 and P = 0.003 for ALDH1 expression and P = 0.012, P = 0.007, P = 0.004 , and P = 0.002 for SOX-9 expression, respectively). There is a significant positive association between the expression of ALDH1 and SOX-9, r (correlation coefficient) = +0.806 (P < 0.001). Local recurrence was associated with the positive expression of ALDH1 only (P = 0.045) and the disease progression was statistically significant and associated with the positive expression of both ALDH1 and SOX-9 (P = 0.038, P = 0.023, respectively). There was significant association of positive expression of SOX-9 with reduced 3-y disease-free survival (P = 0.039). Conclusion: Positive expression of ALDH-1 and SOX9 were associated with aggressive histopathological features and poor outcome in early breast cancer and can be considered potential prognostic markers in this group of patients.https://mejc.sums.ac.ir/article_48392_f4bf7679f66c34a01001b3bf295a94a7.pdfearly breast cancerneoplastic stem cellsaldehyde dehydrogenase 1sox9prognosis |
| spellingShingle | Lobna Abdelaziz Ola Harb Abeer Abdelbary Amrallah Mohammed Hend Elkalla The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer Middle East Journal of Cancer early breast cancer neoplastic stem cells aldehyde dehydrogenase 1 sox9 prognosis |
| title | The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer |
| title_full | The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer |
| title_fullStr | The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer |
| title_full_unstemmed | The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer |
| title_short | The Prognostic Significance of ALDH-1 and SOX9 Expression in Early Breast Cancer |
| title_sort | prognostic significance of aldh 1 and sox9 expression in early breast cancer |
| topic | early breast cancer neoplastic stem cells aldehyde dehydrogenase 1 sox9 prognosis |
| url | https://mejc.sums.ac.ir/article_48392_f4bf7679f66c34a01001b3bf295a94a7.pdf |
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