Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma
Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/11/4/97 |
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| author | Rabia Arshad Mahmood Barani Abbas Rahdar Saman Sargazi Magali Cucchiarini Sadanand Pandey Misook Kang |
| author_facet | Rabia Arshad Mahmood Barani Abbas Rahdar Saman Sargazi Magali Cucchiarini Sadanand Pandey Misook Kang |
| author_sort | Rabia Arshad |
| collection | DOAJ |
| description | Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology. |
| first_indexed | 2024-03-10T12:51:34Z |
| format | Article |
| id | doaj.art-b3570b8a18ed4b4fb5abecb51353af64 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T12:51:34Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b3570b8a18ed4b4fb5abecb51353af642023-11-21T13:02:05ZengMDPI AGBiosensors2079-63742021-03-011149710.3390/bios11040097Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of RetinoblastomaRabia Arshad0Mahmood Barani1Abbas Rahdar2Saman Sargazi3Magali Cucchiarini4Sadanand Pandey5Misook Kang6Department of Pharmacy, Quaid-I-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, ShahidBahonar University of Kerman, Kerman 76169-14111, IranDepartment of Physics, Faculty of Science, University of Zabol, Zabol 98613-35856, IranCellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan 98167-43463, IranCenter of Experimental Orthopaedics, Saarland University Medical Center, 66421 Homburg/Saar, GermanyDepartment of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, KoreaDepartment of Chemistry, College of Natural Science, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, KoreaRetinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology.https://www.mdpi.com/2079-6374/11/4/97retinoblastomarare cancersurface-tailored multi-functionalized nanoparticlesmetallic nanoparticletumor-suppressor gene mutation |
| spellingShingle | Rabia Arshad Mahmood Barani Abbas Rahdar Saman Sargazi Magali Cucchiarini Sadanand Pandey Misook Kang Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma Biosensors retinoblastoma rare cancer surface-tailored multi-functionalized nanoparticles metallic nanoparticle tumor-suppressor gene mutation |
| title | Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma |
| title_full | Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma |
| title_fullStr | Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma |
| title_full_unstemmed | Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma |
| title_short | Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma |
| title_sort | multi functionalized nanomaterials and nanoparticles for diagnosis and treatment of retinoblastoma |
| topic | retinoblastoma rare cancer surface-tailored multi-functionalized nanoparticles metallic nanoparticle tumor-suppressor gene mutation |
| url | https://www.mdpi.com/2079-6374/11/4/97 |
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