Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma?
Background: Endometrioid-type endometrial carcinoma is the most common malignancy of the female genital tract in developed countries. The prognosis greatly depends on the grade and stage of the disease. Aims: In some patients, the disease recurs in a short time after the surgical/medical therapy. He...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=3;spage=418;epage=422;aulast=Celik |
| _version_ | 1818442103201464320 |
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| author | Serkan Y Celik Özgür İlhan Çelik |
| author_facet | Serkan Y Celik Özgür İlhan Çelik |
| author_sort | Serkan Y Celik |
| collection | DOAJ |
| description | Background: Endometrioid-type endometrial carcinoma is the most common malignancy of the female genital tract in developed countries. The prognosis greatly depends on the grade and stage of the disease. Aims: In some patients, the disease recurs in a short time after the surgical/medical therapy. Hence, it is important to predict the patients who will have worse prognosis at the beginning, to choose the appropriate treatment; resuming the search of new prognostic markers. Therefore, our study aimed to detect trophoblast cell surface antigen 2 (TROP2) as a new prognostic marker. Settings and Design: The patients who underwent a hysterectomy and diagnosed with endometrioid-type endometrial carcinoma were evaluated retrospectively and TROP2 immunostain was performed to their tumoral slides. Materials and Methods: We evaluated TROP2 expressions in 102 patients immunohistochemically who underwent hysterectomy with the diagnosis of endometrioid-type endometrial carcinoma histopathologically and correlated them with the other generally accepted prognostic parameters. Statistical Analysis: The Kolmogorov-Smirnov test and Q-Q plot test were used to verify the normality of the distribution of continuous variables. The Chi-square/Fisher's exact tests were used for categorical variables. Analyses were performed with SPSS Statistics for Windows, Version 20. Results: High overexpression of TROP2 was seen in larger, higher-grade, deeper-invasive tumors, tumors with vascular invasion, and pelvic-lymph-node metastasis. These results were statistically significant (P ≤ 0.05). Conclusion: Overexpression of TROP2 in endometrioid-type endometrial carcinoma seems to be a poor prognostic factor; it may be useful in determining the biologically more aggressive tumors before the treatment. This early determination is very important to choose the appropriate surgery, adjuvant-treatments, and follow-up. |
| first_indexed | 2024-12-14T18:38:49Z |
| format | Article |
| id | doaj.art-b3574cd91bc54371a8e95f64914651f4 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-14T18:38:49Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-b3574cd91bc54371a8e95f64914651f42022-12-21T22:51:33ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292020-01-0163341842210.4103/IJPM.IJPM_783_19Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma?Serkan Y CelikÖzgür İlhan ÇelikBackground: Endometrioid-type endometrial carcinoma is the most common malignancy of the female genital tract in developed countries. The prognosis greatly depends on the grade and stage of the disease. Aims: In some patients, the disease recurs in a short time after the surgical/medical therapy. Hence, it is important to predict the patients who will have worse prognosis at the beginning, to choose the appropriate treatment; resuming the search of new prognostic markers. Therefore, our study aimed to detect trophoblast cell surface antigen 2 (TROP2) as a new prognostic marker. Settings and Design: The patients who underwent a hysterectomy and diagnosed with endometrioid-type endometrial carcinoma were evaluated retrospectively and TROP2 immunostain was performed to their tumoral slides. Materials and Methods: We evaluated TROP2 expressions in 102 patients immunohistochemically who underwent hysterectomy with the diagnosis of endometrioid-type endometrial carcinoma histopathologically and correlated them with the other generally accepted prognostic parameters. Statistical Analysis: The Kolmogorov-Smirnov test and Q-Q plot test were used to verify the normality of the distribution of continuous variables. The Chi-square/Fisher's exact tests were used for categorical variables. Analyses were performed with SPSS Statistics for Windows, Version 20. Results: High overexpression of TROP2 was seen in larger, higher-grade, deeper-invasive tumors, tumors with vascular invasion, and pelvic-lymph-node metastasis. These results were statistically significant (P ≤ 0.05). Conclusion: Overexpression of TROP2 in endometrioid-type endometrial carcinoma seems to be a poor prognostic factor; it may be useful in determining the biologically more aggressive tumors before the treatment. This early determination is very important to choose the appropriate surgery, adjuvant-treatments, and follow-up.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=3;spage=418;epage=422;aulast=Celikendometrioid carcinomaimmunohistochemistryprognostic markertrop2 |
| spellingShingle | Serkan Y Celik Özgür İlhan Çelik Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? Indian Journal of Pathology and Microbiology endometrioid carcinoma immunohistochemistry prognostic marker trop2 |
| title | Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? |
| title_full | Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? |
| title_fullStr | Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? |
| title_full_unstemmed | Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? |
| title_short | Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma? |
| title_sort | can trop2 be used as a prognostic marker in endometrioid endometrial carcinoma |
| topic | endometrioid carcinoma immunohistochemistry prognostic marker trop2 |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=3;spage=418;epage=422;aulast=Celik |
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