Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

IntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed. These molecules present antigenic peptides to CD8+ T lymphocytes and natura...

Descripció completa

Dades bibliogràfiques
Autors principals:	Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak
Format:	Article
Idioma:	English
Publicat:	Frontiers Media S.A. 2025-01-01
Col·lecció:	Frontiers in Immunology
Matèries:	rheumatoid arthritis MHC I class ERAP1 ERAP2 single nucleotide polymorphisms
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519159/full

Ítems similars

Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
per: Shuqiong Zhang, et al.
Publicat: (2020-11-01)

The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis
per: Shi-Hong Su, et al.
Publicat: (2025-02-01)

The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
per: Fabiana Paladini, et al.
Publicat: (2020-07-01)

Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions
per: Irma Saulle, et al.
Publicat: (2025-01-01)

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
per: Benedetta Mattorre, et al.
Publicat: (2022-09-01)

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins
per: José A. López de Castro
Publicat: (2018-10-01)

An Overview on ERAP Roles in Infectious Diseases
per: Irma Saulle, et al.
Publicat: (2020-03-01)

Expression and role of ERAP1 in placental tissues of preeclampsia
per: Yanyan Xu, et al.
Publicat: (2020-04-01)

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure
per: Karolina Piekarska, et al.
Publicat: (2021-10-01)

The Role of Aminopeptidase ERAP1 in Human Pathology—A Review
per: Laura Țiburcă, et al.
Publicat: (2024-02-01)

The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response
per: Siri Sæterstad, et al.
Publicat: (2024-08-01)

ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia
per: Xin Li, et al.
Publicat: (2024-11-01)

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs
per: Wouter J. Venema, et al.
Publicat: (2024-01-01)

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
per: Wouter J. Venema, et al.
Publicat: (2021-02-01)

ERAP2 Is Associated With Immune Infiltration and Predicts Favorable Prognosis in SqCLC
per: Zhenlin Yang, et al.
Publicat: (2021-12-01)

Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
per: Patrizia Tempora, et al.
Publicat: (2024-10-01)

Down-regulation of ERAP1 mRNA expression in non-small cell lung cancer
per: Marta Wagner, et al.
Publicat: (2023-04-01)

Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection
per: Irma Saulle, et al.
Publicat: (2019-07-01)

THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS
per: Laura Ioana Cherciu, et al.
Publicat: (2016-06-01)

A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
per: Irma Saulle, et al.
Publicat: (2020-08-01)

Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia
per: Fabiana Paladini, et al.
Publicat: (2019-01-01)

Association of <i>ERAP1</i> and <i>IL23R</i> gene polymorphisms with ankylosing spondylitis
per: U. A. Yakubova, et al.
Publicat: (2020-09-01)

Functional <i>ERAP1</i> Variants Distinctively Associate with Ankylosing Spondylitis Susceptibility under the Influence of <i>HLA-B27</i> in Taiwanese
per: Chin-Man Wang, et al.
Publicat: (2022-08-01)

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2
per: Piotr Kuśnierczyk
Publicat: (2022-06-01)

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism
per: Alina Steinbach, et al.
Publicat: (2017-07-01)

ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function
per: Silvia D’Amico, et al.
Publicat: (2021-11-01)

Multifactor dimensionality reduction reveals the effect of interaction between ERAP1 and IFIH1 polymorphisms in psoriasis susceptibility genes
per: Chang Zhang, et al.
Publicat: (2022-11-01)

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers
per: Andrzej Wiśniewski, et al.
Publicat: (2021-05-01)

Editorial: Insights in antigen presenting cell biology: 2021
per: Peter van Endert, et al.
Publicat: (2022-11-01)

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases
per: Athanasios Papakyriakou, et al.
Publicat: (2017-08-01)

The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
per: Adrian Martín-Esteban, et al.
Publicat: (2022-12-01)

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
per: Leonardo Capistrano Ferreira, et al.
Publicat: (2021-03-01)

The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia
per: Kimberly Seamon, et al.
Publicat: (2020-03-01)

Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
per: Athanasios Papakyriakou, et al.
Publicat: (2022-04-01)

ERAP1 and ankylosing spondylitis.
per: Keidel, S, et al.
Publicat: (2013)

ERAP1 inhibitor development
per: Guzanov, P
Publicat: (2017)

Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
per: Akbulut Ekrem, et al.
Publicat: (2022-03-01)

Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile
per: Hanson, A, et al.
Publicat: (2017)

Concerted in vitro trimming of viral HLA-B27-restricted ligands by human ERAP1 and ERAP2 aminopeptidases.
per: Elena Lorente, et al.
Publicat: (2013-01-01)

Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis
per: Jianhua Zhang, et al.
Publicat: (2024-01-01)