Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

IntroductionRheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed. These molecules present antigenic peptides to CD8+ T lymphocytes and natura...

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Detalhes bibliográficos
Principais autores: Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2025-01-01
coleção:Frontiers in Immunology
Assuntos:
rheumatoid arthritis
MHC I class
ERAP1
ERAP2
single nucleotide polymorphisms
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519159/full

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