Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study
Abstract Background Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional Mendelian randomization (MR) study t...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-022-01180-5 |
| _version_ | 1819277169960943616 |
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| author | Lu Chen Xingang Sun Yuxian He Yunlong Lu Liangrong Zheng |
| author_facet | Lu Chen Xingang Sun Yuxian He Yunlong Lu Liangrong Zheng |
| author_sort | Lu Chen |
| collection | DOAJ |
| description | Abstract Background Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional Mendelian randomization (MR) study to clarify the causal inference between OSA and AF. Methods Genetic instruments for OSA and AF were obtained from genome-wide association studies. The fixed-effects inverse-variance weighted (IVW) method was used as the main method, supplemented by several sensitivity analyses. For replication, another AF dataset was used to validate the causal effect of OSA on AF. Furthermore, multivariable MR analyses were performed to obtain direct estimates adjusting for potential confounders. Results Genetic liability to OSA was found to be significantly associated with a higher AF risk in the fixed-effects IVW method [odds ratio (OR) 1.210; 95% CI 1.119–1.307; P = 1.51 × 10–6]. The results were consistent in MR sensitivity analyses as well as in replication analyses, and the significance remained after adjusting for potential confounders. In the reverse MR analyses, there was no causal effect of AF on OSA. Conclusions Our study strengthened the causal evidence of genetically predicted OSA with a higher AF risk. Early screening and appropriate management of OSA might show anti-arrhythmic benefits. |
| first_indexed | 2024-12-23T23:51:51Z |
| format | Article |
| id | doaj.art-b359a60761f144f791f1ceff60f881d0 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-12-23T23:51:51Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-b359a60761f144f791f1ceff60f881d02022-12-21T17:25:22ZengBMCBMC Medical Genomics1755-87942022-02-011511810.1186/s12920-022-01180-5Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization studyLu Chen0Xingang Sun1Yuxian He2Yunlong Lu3Liangrong Zheng4Department of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Background Observational studies have suggested that obstructive sleep apnea (OSA) is in relation to atrial fibrillation (AF); however, these studies might be confounded and whether the relationship is causal remains unclear. We conducted a bidirectional Mendelian randomization (MR) study to clarify the causal inference between OSA and AF. Methods Genetic instruments for OSA and AF were obtained from genome-wide association studies. The fixed-effects inverse-variance weighted (IVW) method was used as the main method, supplemented by several sensitivity analyses. For replication, another AF dataset was used to validate the causal effect of OSA on AF. Furthermore, multivariable MR analyses were performed to obtain direct estimates adjusting for potential confounders. Results Genetic liability to OSA was found to be significantly associated with a higher AF risk in the fixed-effects IVW method [odds ratio (OR) 1.210; 95% CI 1.119–1.307; P = 1.51 × 10–6]. The results were consistent in MR sensitivity analyses as well as in replication analyses, and the significance remained after adjusting for potential confounders. In the reverse MR analyses, there was no causal effect of AF on OSA. Conclusions Our study strengthened the causal evidence of genetically predicted OSA with a higher AF risk. Early screening and appropriate management of OSA might show anti-arrhythmic benefits.https://doi.org/10.1186/s12920-022-01180-5Obstructive sleep apneaAtrial fibrillationMendelian randomizationBidirectionalCausality |
| spellingShingle | Lu Chen Xingang Sun Yuxian He Yunlong Lu Liangrong Zheng Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study BMC Medical Genomics Obstructive sleep apnea Atrial fibrillation Mendelian randomization Bidirectional Causality |
| title | Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study |
| title_full | Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study |
| title_fullStr | Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study |
| title_full_unstemmed | Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study |
| title_short | Obstructive sleep apnea and atrial fibrillation: insights from a bidirectional Mendelian randomization study |
| title_sort | obstructive sleep apnea and atrial fibrillation insights from a bidirectional mendelian randomization study |
| topic | Obstructive sleep apnea Atrial fibrillation Mendelian randomization Bidirectional Causality |
| url | https://doi.org/10.1186/s12920-022-01180-5 |
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