Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases
It is not clear whether magnetic resonance imaging (MRI) is useful for the assessment of pleural diseases. The aim of this study is to determine whether diffusion-weighted magnetic resonance imaging (DWI) can differentiate malignant pleural mesothelioma (MPM) from pleural dissemination of lung cance...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/6/811 |
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| author | Katsuo Usuda Shun Iwai Aika Funasaki Atsushi Sekimura Nozomu Motono Munetaka Matoba Mariko Doai Sohsuke Yamada Yoshimichi Ueda Hidetaka Uramoto |
| author_facet | Katsuo Usuda Shun Iwai Aika Funasaki Atsushi Sekimura Nozomu Motono Munetaka Matoba Mariko Doai Sohsuke Yamada Yoshimichi Ueda Hidetaka Uramoto |
| author_sort | Katsuo Usuda |
| collection | DOAJ |
| description | It is not clear whether magnetic resonance imaging (MRI) is useful for the assessment of pleural diseases. The aim of this study is to determine whether diffusion-weighted magnetic resonance imaging (DWI) can differentiate malignant pleural mesothelioma (MPM) from pleural dissemination of lung cancer, empyema or pleural effusion. The DWI was calibrated with the b value of 0 and 800 s/mm<sup>2</sup>. There were 11 MPMs (8 epithelioid and 3 biphasic), 10 pleural disseminations of lung cancer, 10 empyemas, and 12 pleural effusions. The apparent diffusion coefficient (ADC) of the pleural diseases was 1.22 ± 0.25 × 10<sup>−3</sup> mm<sup>2</sup>/s in the MPMs, 1.31 ± 0.49 × 10<sup>−3</sup> mm<sup>2</sup>/s in the pleural disseminations, 2.01 ± 0.45 × 10<sup>−3</sup> mm<sup>2</sup>/s in the empyemas and 3.76 ± 0.62 × 10<sup>−3</sup> mm<sup>2</sup>/s in the pleural effusions. The ADC of the MPMs and the pleural disseminations were significantly lower than the ADC of the empyemas and the pleural effusions. Concerning the diffusion pattern of DWI, all 11 MPMs showed strong continuous diffusion, 9 of 10 pleural disseminations showed strong scattered diffusion and 1 pleural dissemination showed strong continuous diffusion, all 10 empyemas showed weak continuous diffusion, and all 12 pleural effusions showed no decreased diffusion. DWI can evaluate pleural diseases morphologically and qualitatively, and thus differentiate between malignant and benign pleural diseases. |
| first_indexed | 2024-03-12T19:18:42Z |
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| id | doaj.art-b35c10a2007f4902a78d274568a4bea5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:18:42Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b35c10a2007f4902a78d274568a4bea52023-08-02T05:22:03ZengMDPI AGCancers2072-66942019-06-0111681110.3390/cancers11060811cancers11060811Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural DiseasesKatsuo Usuda0Shun Iwai1Aika Funasaki2Atsushi Sekimura3Nozomu Motono4Munetaka Matoba5Mariko Doai6Sohsuke Yamada7Yoshimichi Ueda8Hidetaka Uramoto9Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Radiology, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Radiology, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Pathophysiological and Experimental Pathology, Kanazawa Medical University, Ishikawa 920-0293, JapanDepartment of Thoracic Surgery, Kanazawa Medical University, Ishikawa 920-0293, JapanIt is not clear whether magnetic resonance imaging (MRI) is useful for the assessment of pleural diseases. The aim of this study is to determine whether diffusion-weighted magnetic resonance imaging (DWI) can differentiate malignant pleural mesothelioma (MPM) from pleural dissemination of lung cancer, empyema or pleural effusion. The DWI was calibrated with the b value of 0 and 800 s/mm<sup>2</sup>. There were 11 MPMs (8 epithelioid and 3 biphasic), 10 pleural disseminations of lung cancer, 10 empyemas, and 12 pleural effusions. The apparent diffusion coefficient (ADC) of the pleural diseases was 1.22 ± 0.25 × 10<sup>−3</sup> mm<sup>2</sup>/s in the MPMs, 1.31 ± 0.49 × 10<sup>−3</sup> mm<sup>2</sup>/s in the pleural disseminations, 2.01 ± 0.45 × 10<sup>−3</sup> mm<sup>2</sup>/s in the empyemas and 3.76 ± 0.62 × 10<sup>−3</sup> mm<sup>2</sup>/s in the pleural effusions. The ADC of the MPMs and the pleural disseminations were significantly lower than the ADC of the empyemas and the pleural effusions. Concerning the diffusion pattern of DWI, all 11 MPMs showed strong continuous diffusion, 9 of 10 pleural disseminations showed strong scattered diffusion and 1 pleural dissemination showed strong continuous diffusion, all 10 empyemas showed weak continuous diffusion, and all 12 pleural effusions showed no decreased diffusion. DWI can evaluate pleural diseases morphologically and qualitatively, and thus differentiate between malignant and benign pleural diseases.https://www.mdpi.com/2072-6694/11/6/811magnetic resonance imagingdiffusion-weighted imagingmalignant pleural mesotheliomapleural disseminationempyemapleural effusion |
| spellingShingle | Katsuo Usuda Shun Iwai Aika Funasaki Atsushi Sekimura Nozomu Motono Munetaka Matoba Mariko Doai Sohsuke Yamada Yoshimichi Ueda Hidetaka Uramoto Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases Cancers magnetic resonance imaging diffusion-weighted imaging malignant pleural mesothelioma pleural dissemination empyema pleural effusion |
| title | Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases |
| title_full | Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases |
| title_fullStr | Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases |
| title_full_unstemmed | Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases |
| title_short | Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases |
| title_sort | diffusion weighted imaging can differentiate between malignant and benign pleural diseases |
| topic | magnetic resonance imaging diffusion-weighted imaging malignant pleural mesothelioma pleural dissemination empyema pleural effusion |
| url | https://www.mdpi.com/2072-6694/11/6/811 |
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