Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review
<b>Purpose:</b> To investigate the relationship between glaucoma, pseudoexfoliation and hearing loss (HL). <b>Methods</b>: A systematic literature search following PRISMA guidelines was conducted using the PubMed, Embase, Scopus and Cochrane databases from 1995 up to 28 Augus...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1379 |
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| author | Laura Antonia Meliante Giulia Piccotti Lucia Tanga Sara Giammaria Gianluca Manni Giulia Coco |
| author_facet | Laura Antonia Meliante Giulia Piccotti Lucia Tanga Sara Giammaria Gianluca Manni Giulia Coco |
| author_sort | Laura Antonia Meliante |
| collection | DOAJ |
| description | <b>Purpose:</b> To investigate the relationship between glaucoma, pseudoexfoliation and hearing loss (HL). <b>Methods</b>: A systematic literature search following PRISMA guidelines was conducted using the PubMed, Embase, Scopus and Cochrane databases from 1995 up to 28 August 2023. <b>Results</b>: Thirty studies out of the 520 records screened met the inclusion criteria and were included. Most articles (n = 20) analysed the association between pseudoexfoliation syndrome (XFS) and HL, showing XFS patients to have higher prevalence of sensorineural hearing loss (SNHL) at both speech frequencies (0.25, 0.5, 1 and 2 kHz), and higher frequencies (4 and 8 kHz) compared to controls in most cases. No significant differences in prevalence or level of HL between XFS and pseudoexfoliative glaucoma (XFG) were detected in most studies. Eight articles analysed the relationship between primary open-angle glaucoma (POAG) and HL. Overall, a positive association between the two conditions was highlighted across all studies except for two cases. Similarly, articles focusing on NTG and HL (n = 4) showed a positive association in most cases. The role of autoimmunity and, in particular, the presence of antiphosphatidylserine antibodies (APSA) in patients with NTG and HL suggested an underlying autoimmune or vascular mechanism contributing to their pathogenesis. Only one study analysed the relationship between angle-closure glaucoma (ACG) and HL, showing higher incidence of ACG in patients with SNHL compared to normal hearing controls. <b>Conclusions</b>: Most studies detected an association between XFS and HL as well as POAG/NTG/ACG and HL, suggesting the presence of a similar pathophysiology of neurodegeneration. However, given the strength of the association of XFS with HL, it remains unclear whether the presence of XFG is further associated with SNHL. Further research specifically targeted to assess the correlation between glaucoma, XFS and HL is warranted to provide a more comprehensive understanding of this association. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:56Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b35cbbb014984d4f9c327e2215b2fb7e2024-03-12T16:48:14ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135137910.3390/jcm13051379Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature ReviewLaura Antonia Meliante0Giulia Piccotti1Lucia Tanga2Sara Giammaria3Gianluca Manni4Giulia Coco5Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyIRCCS—Fondazione Bietti, 00184 Rome, ItalyIRCCS—Fondazione Bietti, 00184 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy<b>Purpose:</b> To investigate the relationship between glaucoma, pseudoexfoliation and hearing loss (HL). <b>Methods</b>: A systematic literature search following PRISMA guidelines was conducted using the PubMed, Embase, Scopus and Cochrane databases from 1995 up to 28 August 2023. <b>Results</b>: Thirty studies out of the 520 records screened met the inclusion criteria and were included. Most articles (n = 20) analysed the association between pseudoexfoliation syndrome (XFS) and HL, showing XFS patients to have higher prevalence of sensorineural hearing loss (SNHL) at both speech frequencies (0.25, 0.5, 1 and 2 kHz), and higher frequencies (4 and 8 kHz) compared to controls in most cases. No significant differences in prevalence or level of HL between XFS and pseudoexfoliative glaucoma (XFG) were detected in most studies. Eight articles analysed the relationship between primary open-angle glaucoma (POAG) and HL. Overall, a positive association between the two conditions was highlighted across all studies except for two cases. Similarly, articles focusing on NTG and HL (n = 4) showed a positive association in most cases. The role of autoimmunity and, in particular, the presence of antiphosphatidylserine antibodies (APSA) in patients with NTG and HL suggested an underlying autoimmune or vascular mechanism contributing to their pathogenesis. Only one study analysed the relationship between angle-closure glaucoma (ACG) and HL, showing higher incidence of ACG in patients with SNHL compared to normal hearing controls. <b>Conclusions</b>: Most studies detected an association between XFS and HL as well as POAG/NTG/ACG and HL, suggesting the presence of a similar pathophysiology of neurodegeneration. However, given the strength of the association of XFS with HL, it remains unclear whether the presence of XFG is further associated with SNHL. Further research specifically targeted to assess the correlation between glaucoma, XFS and HL is warranted to provide a more comprehensive understanding of this association.https://www.mdpi.com/2077-0383/13/5/1379glaucomahearing losspseudoexfoliationPOAGNTG |
| spellingShingle | Laura Antonia Meliante Giulia Piccotti Lucia Tanga Sara Giammaria Gianluca Manni Giulia Coco Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review Journal of Clinical Medicine glaucoma hearing loss pseudoexfoliation POAG NTG |
| title | Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review |
| title_full | Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review |
| title_fullStr | Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review |
| title_full_unstemmed | Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review |
| title_short | Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review |
| title_sort | glaucoma pseudoexfoliation and hearing loss a systematic literature review |
| topic | glaucoma hearing loss pseudoexfoliation POAG NTG |
| url | https://www.mdpi.com/2077-0383/13/5/1379 |
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