Different clinical symptom patterns in patients with reflux micro-aspiration
Background Pulmonary manifestation of gastro-oesophageal reflux disease (GORD) is a well-recognised entity; however, little primary reported data exists on presenting symptoms of patients in whom reflux micro-aspiration is confirmed. The aim of this study is to report symptoms and presenting pattern...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2022-01-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/1/00508-2021.full |
| _version_ | 1819018196656586752 |
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| author | Oleksandr Khoma Jin-soo Park Felix Michael Lee Hans Van der Wall Gregory L. Falk |
| author_facet | Oleksandr Khoma Jin-soo Park Felix Michael Lee Hans Van der Wall Gregory L. Falk |
| author_sort | Oleksandr Khoma |
| collection | DOAJ |
| description | Background
Pulmonary manifestation of gastro-oesophageal reflux disease (GORD) is a well-recognised entity; however, little primary reported data exists on presenting symptoms of patients in whom reflux micro-aspiration is confirmed. The aim of this study is to report symptoms and presenting patterns of a large group of patients with confirmed reflux micro-aspiration.
Patients and methods
Data was extracted from a prospectively populated database of patients referred to a tertiary specialist centre with severe, refractory or atypical reflux. Patients with reflux micro-aspiration on scintigraphy were included in this study. A separate group included patients with evidence of proximal reflux to the level of pharynx when supine and/or upright.
Results
Inclusion criteria were met by 243 patients with confirmed reflux micro-aspiration (33% males; mean age 59). Most common symptoms amongst patients with micro-aspiration were regurgitation (72%), cough (67%), heartburn (66%), throat clearing (65%) and dysphonia (53%). The most common two-symptom combinations were heartburn/regurgitation, cough/throat clearing, regurgitation/throat clearing, cough/regurgitation and dysphonia/throat clearing. The most common three-symptom combinations were cough/heartburn/regurgitation, cough/regurgitation/throat clearing and dysphonia/regurgitation/throat clearing. Cluster analysis demonstrated two main symptom groupings, one suggestive of proximal volume reflux symptoms and the other with motility/inflammatory bowel syndrome-like symptoms (bloat, constipation).
Conclusion
The combination of typical symptoms of GORD such as heartburn or regurgitation and a respiratory or upper aero-digestive complaint such as cough, throat clearing or voice change should prompt consideration of reflux micro-aspiration. |
| first_indexed | 2024-12-21T03:15:35Z |
| format | Article |
| id | doaj.art-b35d35fce0c3450a8fdf0552ee0cbbc0 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-21T03:15:35Z |
| publishDate | 2022-01-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-b35d35fce0c3450a8fdf0552ee0cbbc02022-12-21T19:17:52ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-01-018110.1183/23120541.00508-202100508-2021Different clinical symptom patterns in patients with reflux micro-aspirationOleksandr Khoma0Jin-soo Park1Felix Michael Lee2Hans Van der Wall3Gregory L. Falk4 University of Notre Dame, Freemantle, Australia University of Notre Dame, Freemantle, Australia Dept of Upper Gastro-Intestinal Surgery, Concord Repatriation General Hospital, Sydney, Australia University of Notre Dame, Freemantle, Australia Dept of Upper Gastro-Intestinal Surgery, Concord Repatriation General Hospital, Sydney, Australia Background Pulmonary manifestation of gastro-oesophageal reflux disease (GORD) is a well-recognised entity; however, little primary reported data exists on presenting symptoms of patients in whom reflux micro-aspiration is confirmed. The aim of this study is to report symptoms and presenting patterns of a large group of patients with confirmed reflux micro-aspiration. Patients and methods Data was extracted from a prospectively populated database of patients referred to a tertiary specialist centre with severe, refractory or atypical reflux. Patients with reflux micro-aspiration on scintigraphy were included in this study. A separate group included patients with evidence of proximal reflux to the level of pharynx when supine and/or upright. Results Inclusion criteria were met by 243 patients with confirmed reflux micro-aspiration (33% males; mean age 59). Most common symptoms amongst patients with micro-aspiration were regurgitation (72%), cough (67%), heartburn (66%), throat clearing (65%) and dysphonia (53%). The most common two-symptom combinations were heartburn/regurgitation, cough/throat clearing, regurgitation/throat clearing, cough/regurgitation and dysphonia/throat clearing. The most common three-symptom combinations were cough/heartburn/regurgitation, cough/regurgitation/throat clearing and dysphonia/regurgitation/throat clearing. Cluster analysis demonstrated two main symptom groupings, one suggestive of proximal volume reflux symptoms and the other with motility/inflammatory bowel syndrome-like symptoms (bloat, constipation). Conclusion The combination of typical symptoms of GORD such as heartburn or regurgitation and a respiratory or upper aero-digestive complaint such as cough, throat clearing or voice change should prompt consideration of reflux micro-aspiration.http://openres.ersjournals.com/content/8/1/00508-2021.full |
| spellingShingle | Oleksandr Khoma Jin-soo Park Felix Michael Lee Hans Van der Wall Gregory L. Falk Different clinical symptom patterns in patients with reflux micro-aspiration ERJ Open Research |
| title | Different clinical symptom patterns in patients with reflux micro-aspiration |
| title_full | Different clinical symptom patterns in patients with reflux micro-aspiration |
| title_fullStr | Different clinical symptom patterns in patients with reflux micro-aspiration |
| title_full_unstemmed | Different clinical symptom patterns in patients with reflux micro-aspiration |
| title_short | Different clinical symptom patterns in patients with reflux micro-aspiration |
| title_sort | different clinical symptom patterns in patients with reflux micro aspiration |
| url | http://openres.ersjournals.com/content/8/1/00508-2021.full |
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