Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils

Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils

Neutrophil extracellular traps (NETs) are cytotoxic DNA-protein complexes that play positive and negative roles in combating infection, inflammation, organ damage, autoimmunity, sepsis and cancer. However, NETosis regulatory effects of most of the clinically used drugs are not clearly established. S...

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Bibliographic Details
Main Authors: Meraj A. Khan, Adam D’Ovidio, Harvard Tran, Nades Palaniyar
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
drug screening
anthracyclines
DNA-metabolism inhibitors
neutrophil extracellular trap (NET)
Nox-dependent and -independent NETosis
Online Access:https://www.mdpi.com/2072-6694/11/9/1328

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