Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD). Evidence suggests that ALS is a ‘dying-back’ disease, with peripheral denervation and axonal degeneration occurring...

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Bibliographic Details
Main Authors: Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Acta Neuropathologica Communications
Subjects:
Sterile alpha and TIR motif-containing protein 1
Amyotrophic lateral sclerosis
TAR DNA-binding protein 43
Wallerian degeneration
Axonal protection
Dendritic spines
Online Access:http://link.springer.com/article/10.1186/s40478-019-0800-9

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