Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome
Background: Sjögren’s syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their dail...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.645437/full |
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| author | Ching-Mao Chang Ching-Mao Chang Ching-Mao Chang Po-Chang Wu Po-Chang Wu Jr-Rung Lin Yeong-Jian Jan Wu Shue-Fen Luo Yin-Tzu Hsue Joung-Liang Lan Joung-Liang Lan Tai-Long Pan Tai-Long Pan Tai-Long Pan Yu-Ting Wu Kuang-Hui Yu Yau-Huei Wei Yau-Huei Wei Yau-Huei Wei Hen-Hong Chang Hen-Hong Chang |
| author_facet | Ching-Mao Chang Ching-Mao Chang Ching-Mao Chang Po-Chang Wu Po-Chang Wu Jr-Rung Lin Yeong-Jian Jan Wu Shue-Fen Luo Yin-Tzu Hsue Joung-Liang Lan Joung-Liang Lan Tai-Long Pan Tai-Long Pan Tai-Long Pan Yu-Ting Wu Kuang-Hui Yu Yau-Huei Wei Yau-Huei Wei Yau-Huei Wei Hen-Hong Chang Hen-Hong Chang |
| author_sort | Ching-Mao Chang |
| collection | DOAJ |
| description | Background: Sjögren’s syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their daily activities.Objective: This study aims to evaluate the efficacy of the herbal formula SS-1 for its potential therapeutic benefits for patients with Sjögren’s syndrome.Materials and Methods: The bioactivity profile of SS-1 was determined using four different SS-1 concentrations across 12 human primary cell systems of the BioMAP profile. After that, a randomized, double-blind, crossover, placebo-controlled trial was performed including 57 patients treated with SS-1 for 28 weeks.Results: Biologically multiplexed activity profiling in cell-based models indicated that SS-1 exerted anti-proliferative activity in B cells and promoted anti-inflammatory and immunomodulatory activity. In the clinical trial, Schirmer’s test results revealed significant improvements in both eyes, with increases of 3.42 mm (95% CI, 2.44–4.41 mm) and 3.45 mm (95% CI, 2.32–4.59 mm), respectively, and a significant reduction in artificial tear use, which was −1.38 times/day, 95% CI, −1.95 to −0.81 times/day. Moreover, the increases in B-cell activating factor (BAFF) and B-cell maturation antigen (BCMA) levels were dampened by 53.20% (295.29 versus 555.02 pg/ml) and 58.33% (99.16 versus 169.99 pg/ml), respectively.Conclusion: SS-1 treatment significantly inhibited B-cell maturation antigen. No serious drug-related adverse effects were observed. Oral SS-1 administration may be a complementary treatment for Sjögren’s syndrome. |
| first_indexed | 2024-12-22T10:50:23Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T10:50:23Z |
| publishDate | 2021-09-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-b3613331f6d04ac7a83a941707fe7c962022-12-21T18:28:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.645437645437Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s SyndromeChing-Mao Chang0Ching-Mao Chang1Ching-Mao Chang2Po-Chang Wu3Po-Chang Wu4Jr-Rung Lin5Yeong-Jian Jan Wu6Shue-Fen Luo7Yin-Tzu Hsue8Joung-Liang Lan9Joung-Liang Lan10Tai-Long Pan11Tai-Long Pan12Tai-Long Pan13Yu-Ting Wu14Kuang-Hui Yu15Yau-Huei Wei16Yau-Huei Wei17Yau-Huei Wei18Hen-Hong Chang19Hen-Hong Chang20Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanClinical Informatics and Medical Statistics Research Center, Graduate Institute of Clinical Medical, Chang Gung University, Taoyuan, TaiwanDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Changhua Christian Hospital, Changhua, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanSchool of Traditional Chinese Medicine and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan0Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan1Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan2Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua, TaiwanDepartment of Medicine, Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan2Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua, Taiwan3Department of Biochemistry and Molecular Biology, School of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan4Department of Medicine, Mackay Medical College, Taipei, Taiwan5Graduate Institute of Integrated Medicine, College of Chinese Medicine, and Chinese Medicine Research Center, China Medical University, Taichung, Taiwan6Department of Chinese Medicine, China Medical University Hospital, Taichung, TaiwanBackground: Sjögren’s syndrome (SS) is an autoimmune inflammatory disease that primarily affects the exocrine glands, leading to glandular dysfunction. The hallmark symptoms of SS are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their daily activities.Objective: This study aims to evaluate the efficacy of the herbal formula SS-1 for its potential therapeutic benefits for patients with Sjögren’s syndrome.Materials and Methods: The bioactivity profile of SS-1 was determined using four different SS-1 concentrations across 12 human primary cell systems of the BioMAP profile. After that, a randomized, double-blind, crossover, placebo-controlled trial was performed including 57 patients treated with SS-1 for 28 weeks.Results: Biologically multiplexed activity profiling in cell-based models indicated that SS-1 exerted anti-proliferative activity in B cells and promoted anti-inflammatory and immunomodulatory activity. In the clinical trial, Schirmer’s test results revealed significant improvements in both eyes, with increases of 3.42 mm (95% CI, 2.44–4.41 mm) and 3.45 mm (95% CI, 2.32–4.59 mm), respectively, and a significant reduction in artificial tear use, which was −1.38 times/day, 95% CI, −1.95 to −0.81 times/day. Moreover, the increases in B-cell activating factor (BAFF) and B-cell maturation antigen (BCMA) levels were dampened by 53.20% (295.29 versus 555.02 pg/ml) and 58.33% (99.16 versus 169.99 pg/ml), respectively.Conclusion: SS-1 treatment significantly inhibited B-cell maturation antigen. No serious drug-related adverse effects were observed. Oral SS-1 administration may be a complementary treatment for Sjögren’s syndrome.https://www.frontiersin.org/articles/10.3389/fphar.2021.645437/fullSjögren’s syndromeXerophthalmiaHerbal formulaIntegrative therapySS-1 |
| spellingShingle | Ching-Mao Chang Ching-Mao Chang Ching-Mao Chang Po-Chang Wu Po-Chang Wu Jr-Rung Lin Yeong-Jian Jan Wu Shue-Fen Luo Yin-Tzu Hsue Joung-Liang Lan Joung-Liang Lan Tai-Long Pan Tai-Long Pan Tai-Long Pan Yu-Ting Wu Kuang-Hui Yu Yau-Huei Wei Yau-Huei Wei Yau-Huei Wei Hen-Hong Chang Hen-Hong Chang Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome Frontiers in Pharmacology Sjögren’s syndrome Xerophthalmia Herbal formula Integrative therapy SS-1 |
| title | Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome |
| title_full | Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome |
| title_fullStr | Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome |
| title_full_unstemmed | Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome |
| title_short | Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome |
| title_sort | herbal formula ss 1 increases tear secretion for sjogren s syndrome |
| topic | Sjögren’s syndrome Xerophthalmia Herbal formula Integrative therapy SS-1 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.645437/full |
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