The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions
Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01119-w |
| _version_ | 1818996300150996992 |
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| author | Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski |
| author_facet | Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski |
| author_sort | Alon Herschhorn |
| collection | DOAJ |
| description | Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions. |
| first_indexed | 2024-12-20T21:27:33Z |
| format | Article |
| id | doaj.art-b36161e14e3f46feaa6eadd812d25c74 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:27:33Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b36161e14e3f46feaa6eadd812d25c742022-12-21T19:26:08ZengNature PortfolioNature Communications2041-17232017-10-018111210.1038/s41467-017-01119-wThe β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitionsAlon Herschhorn0Christopher Gu1Francesca Moraca2Xiaochu Ma3Mark Farrell4Amos B. Smith5Marie Pancera6Peter D. Kwong7Arne Schön8Ernesto Freire9Cameron Abrams10Scott C. Blanchard11Walther Mothes12Joseph G. Sodroski13Department of Cancer Immunology and Virology, Dana-Farber Cancer InstituteDepartment of Cancer Immunology and Virology, Dana-Farber Cancer InstituteDepartment of Chemical and Biological Engineering, Drexel UniversityDepartment of Microbial Pathogenesis, Yale University School of MedicineDepartment of Chemistry, University of PennsylvaniaDepartment of Chemistry, University of PennsylvaniaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Biology, Johns Hopkins UniversityDepartment of Biology, Johns Hopkins UniversityDepartment of Chemical and Biological Engineering, Drexel UniversityDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell UniversityDepartment of Microbial Pathogenesis, Yale University School of MedicineDepartment of Cancer Immunology and Virology, Dana-Farber Cancer InstituteBinding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regulator for Env transitions.https://doi.org/10.1038/s41467-017-01119-w |
| spellingShingle | Alon Herschhorn Christopher Gu Francesca Moraca Xiaochu Ma Mark Farrell Amos B. Smith Marie Pancera Peter D. Kwong Arne Schön Ernesto Freire Cameron Abrams Scott C. Blanchard Walther Mothes Joseph G. Sodroski The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions Nature Communications |
| title | The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_full | The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_fullStr | The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_full_unstemmed | The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_short | The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions |
| title_sort | β20 β21 of gp120 is a regulatory switch for hiv 1 env conformational transitions |
| url | https://doi.org/10.1038/s41467-017-01119-w |
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