Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation
<abstract language="eng">The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(e-caprolactone) or Eudragit® RS100, as polymers. Nanocapsule-coated microparticles...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2008-01-01
|
| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800009 |
| _version_ | 1828931732113457152 |
|---|---|
| author | Gislane Scholze Domingues Sílvia Stanisçuaski Guterres Ruy Carlos Ruver Beck Adriana Raffin Pohlmann |
| author_facet | Gislane Scholze Domingues Sílvia Stanisçuaski Guterres Ruy Carlos Ruver Beck Adriana Raffin Pohlmann |
| author_sort | Gislane Scholze Domingues |
| collection | DOAJ |
| description | <abstract language="eng">The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(e-caprolactone) or Eudragit® RS100, as polymers. Nanocapsule-coated microparticles showed micrometric mean sizes (10 - 15 µm) and a reduced surface area (75 - 85 m²g-1) compared to the raw material (214 m²g-1). Microparticles coated with Eudragit® RS100-nanocapsules showed a better control of the drug release. The release profiles fit to the monoexponetial model and to the Power Law. The mechanism of the indomethacin release from the microparticles is non-Fickian and depends on the particles desagglomeration. |
| first_indexed | 2024-12-14T00:51:56Z |
| format | Article |
| id | doaj.art-b3629e8ffe9744558975172509de9730 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-14T00:51:56Z |
| publishDate | 2008-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-b3629e8ffe9744558975172509de97302022-12-21T23:23:47ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642008-01-013181966197210.1590/S0100-40422008000800009Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluationGislane Scholze DominguesSílvia Stanisçuaski GuterresRuy Carlos Ruver BeckAdriana Raffin Pohlmann<abstract language="eng">The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model and poly(e-caprolactone) or Eudragit® RS100, as polymers. Nanocapsule-coated microparticles showed micrometric mean sizes (10 - 15 µm) and a reduced surface area (75 - 85 m²g-1) compared to the raw material (214 m²g-1). Microparticles coated with Eudragit® RS100-nanocapsules showed a better control of the drug release. The release profiles fit to the monoexponetial model and to the Power Law. The mechanism of the indomethacin release from the microparticles is non-Fickian and depends on the particles desagglomeration.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800009indomethacinmicroparticlesnanocapsules |
| spellingShingle | Gislane Scholze Domingues Sílvia Stanisçuaski Guterres Ruy Carlos Ruver Beck Adriana Raffin Pohlmann Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation Química Nova indomethacin microparticles nanocapsules |
| title | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation |
| title_full | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation |
| title_fullStr | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation |
| title_full_unstemmed | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation |
| title_short | Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica Nanocapsule-coated microparticles prepared in one step: characterization and in vitro drug release profiles evaluation |
| title_sort | microparticulas nanorrevestidas contendo um farmaco modelo hidrofobico preparacao em etapa unica e caracterizacao biofarmaceutica nanocapsule coated microparticles prepared in one step characterization and in vitro drug release profiles evaluation |
| topic | indomethacin microparticles nanocapsules |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000800009 |
| work_keys_str_mv | AT gislanescholzedomingues microparticulasnanorrevestidascontendoumfarmacomodelohidrofobicopreparacaoemetapaunicaecaracterizacaobiofarmaceuticananocapsulecoatedmicroparticlespreparedinonestepcharacterizationandinvitrodrugreleaseprofilesevaluation AT silviastaniscuaskiguterres microparticulasnanorrevestidascontendoumfarmacomodelohidrofobicopreparacaoemetapaunicaecaracterizacaobiofarmaceuticananocapsulecoatedmicroparticlespreparedinonestepcharacterizationandinvitrodrugreleaseprofilesevaluation AT ruycarlosruverbeck microparticulasnanorrevestidascontendoumfarmacomodelohidrofobicopreparacaoemetapaunicaecaracterizacaobiofarmaceuticananocapsulecoatedmicroparticlespreparedinonestepcharacterizationandinvitrodrugreleaseprofilesevaluation AT adrianaraffinpohlmann microparticulasnanorrevestidascontendoumfarmacomodelohidrofobicopreparacaoemetapaunicaecaracterizacaobiofarmaceuticananocapsulecoatedmicroparticlespreparedinonestepcharacterizationandinvitrodrugreleaseprofilesevaluation |