Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract
Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/24/16109 |
| _version_ | 1797457218848686080 |
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| author | Kylene M. Harold William M. MacCuaig Jennifer Holter-Charkabarty Kirsten Williams Kaitlyn Hill Alex X. Arreola Malika Sekhri Steven Carter Jorge Gomez-Gutierrez George Salem Girish Mishra Lacey R. McNally |
| author_facet | Kylene M. Harold William M. MacCuaig Jennifer Holter-Charkabarty Kirsten Williams Kaitlyn Hill Alex X. Arreola Malika Sekhri Steven Carter Jorge Gomez-Gutierrez George Salem Girish Mishra Lacey R. McNally |
| author_sort | Kylene M. Harold |
| collection | DOAJ |
| description | Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly emerging technologies such as optoacoustic imaging, many recent advancements have focused on improving upon pre-existing modalities such as ultrasound, computed tomography, magnetic resonance imaging, and endoscopy. These advancements include utilization of machine learning models, biomarkers, new technological applications such as diffusion weighted imaging, and new techniques such as transrectal ultrasound. This review discusses assessment of disease processes using imaging strategies for the detection and monitoring of inflammation, fibrosis, and cancer in the context of gastrointestinal disease. Specifically, we include ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, graft vs. host disease, intestinal fibrosis, colorectal stricture, gastric cancer, and colorectal cancer. We address some of the most recent and promising advancements for improvement of gastrointestinal imaging, including unique discussions of such advancements with regard to imaging of fibrosis and differentiation between similar disease processes. |
| first_indexed | 2024-03-09T16:19:03Z |
| format | Article |
| id | doaj.art-b3638a1c66b147dfbcfe19bb4e492cb9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:19:03Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b3638a1c66b147dfbcfe19bb4e492cb92023-11-24T15:33:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241610910.3390/ijms232416109Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal TractKylene M. Harold0William M. MacCuaig1Jennifer Holter-Charkabarty2Kirsten Williams3Kaitlyn Hill4Alex X. Arreola5Malika Sekhri6Steven Carter7Jorge Gomez-Gutierrez8George Salem9Girish Mishra10Lacey R. McNally11Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Bioengineering, University of Oklahoma, Norman, OK 73019, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USASchool of Medicine, Emory University, Atlanta, GA 30322, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Child Health, School of Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAWake Forest Baptist Health, Winston-Salem, NC 27157, USADepartment of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAGastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly emerging technologies such as optoacoustic imaging, many recent advancements have focused on improving upon pre-existing modalities such as ultrasound, computed tomography, magnetic resonance imaging, and endoscopy. These advancements include utilization of machine learning models, biomarkers, new technological applications such as diffusion weighted imaging, and new techniques such as transrectal ultrasound. This review discusses assessment of disease processes using imaging strategies for the detection and monitoring of inflammation, fibrosis, and cancer in the context of gastrointestinal disease. Specifically, we include ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, graft vs. host disease, intestinal fibrosis, colorectal stricture, gastric cancer, and colorectal cancer. We address some of the most recent and promising advancements for improvement of gastrointestinal imaging, including unique discussions of such advancements with regard to imaging of fibrosis and differentiation between similar disease processes.https://www.mdpi.com/1422-0067/23/24/16109imaginggastrointestinal tractinflammationfibrosiscancer |
| spellingShingle | Kylene M. Harold William M. MacCuaig Jennifer Holter-Charkabarty Kirsten Williams Kaitlyn Hill Alex X. Arreola Malika Sekhri Steven Carter Jorge Gomez-Gutierrez George Salem Girish Mishra Lacey R. McNally Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract International Journal of Molecular Sciences imaging gastrointestinal tract inflammation fibrosis cancer |
| title | Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract |
| title_full | Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract |
| title_fullStr | Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract |
| title_full_unstemmed | Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract |
| title_short | Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract |
| title_sort | advances in imaging of inflammation fibrosis and cancer in the gastrointestinal tract |
| topic | imaging gastrointestinal tract inflammation fibrosis cancer |
| url | https://www.mdpi.com/1422-0067/23/24/16109 |
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